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Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils.

  • 2013-10-15
  • African journal of traditional, complementary, and alternative medicines : AJTCAM 10(6)
    • Soheila Rezapour-Firouzi
    • Seyed Rafie Arefhosseini
    • Mehrangiz Ebrahimi-Mamaghani
    • Mehdi Farhoudi
    • Behzad Baradaran
    • Torbati Mohammad Ali
    • Fatemeh Zamani

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 65
Population
100 RRMS patients with EDSS<6
Methods
Double-blind randomized trial, 100 RRMS patients allocated to three groups: Group A received co-supplemented hemp seed and evening primrose oils with advised Hot nature diet, Group B received olive oil, Group C received the co-supplemented oils; 6 months intervention; gas chromatography analysis
Blinding
Double-blind
Duration
6 months
Funding
Unclear
The risk of developing multiple sclerosis (MS) is associated with increased dietary intake of saturated fatty acids. For many years it has been suspected that this disease might be associated with an imbalance between unsaturated and saturated fatty acids. We determined erythrocyte membrane fatty acids levels in Hot nature dietary intervention with co-supplemented hemp seed and evening primrose oils in multiple sclerosis patients. To determine the erythrocyte membrane fatty acids levels and correlate it with expanded disability status scale (EDSS) at baseline after 6 months intervention in MS patients by gas chromatography, in this double blind, randomized trial, 100 RRMS patients with EDSS<6 were allocated into three groups: "Group A" that received co-supplemented hemp seed and evening primrose oils with advised Hot nature diet. "Group B" received olive oil and "Group C" received the co-supplemented oils. The results showed that the mean follow-up was 180 ± 2.9SD days (N=65, 23 M and 42 F aged 34.25 ± 8.07 years with disease duration of 6.80 ± 4.33 years). There was no significant difference in the study parameters at baseline. After 6 months, EDSS, Immunological parameters and the erythrocyte cell membrane with regard to specific fatty acids showed improvement in the group A and C, whereas there was worsening condition for the group B after the intervention. We concluded that Hot-nature dietary intervention with co-supplemented hemp seed and evening primrose oils caused an increase PUFAs in MS patients and improvement in the erythrocyte membrane fatty acids composition. This could be an indication of restored plasma stores, and a reflection of disease severity reduction.

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