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Evaluation of adhesion properties and antibacterial activities of the infant gut commensal Bifidobacterium bifidum PRL2010.

  • 2013-06
  • Anaerobe 21
    • Fausta Serafini
    • F. Strati
    • P. Ruas-Madiedo
    • F. Turroni
    • Elena Foroni
    • S. Duranti
    • F. Milano
    • Alessio Perotti
    • Alice Viappiani
    • S. Guglielmetti
    • A. Buschini
    • A. Margolles
    • D. van Sinderen
    • M. Ventura

Abstract

Bifidobacteria are extensively exploited by the food industry as health-promoting microorganisms. However, very little is known about the molecular mechanisms responsible for these beneficial activities, or the molecular players that sustain their ability to colonize and persist within the human gut. Here, we have investigated the enteric adaptation features of the gut commensal Bifidobacterium bifidum PRL2010, originally isolated from infant feces. This strain was able to survive under gastrointestinal challenges, while it was shown to adhere to human epithelial intestinal cell monolayers (Caco 2 and HT-29), thereby inhibiting adhesion of pathogenic bacteria such as Escherichia coli and Cronobacter sakazakii.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium bifidumEnhanced Adherence to Intestinal Epithelial CellsBeneficial
Moderate
Bifidobacterium bifidumImproved Survival Under Gastrointestinal ChallengesBeneficial
Moderate
Bifidobacterium bifidumReduced Pathogen AdhesionBeneficial
Moderate

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