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Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study.

  • 2025-04-18
  • Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 97(2)
    • Sameh Fayek GamalEl Din
    • Elnashar A M
    • Yasser Elkhiat
    • Tarek Hussein
    • Mohamed Ahmed AbdElSalam
    • Ayman Alam
    • David Ramzy
    • Islam Moatamed
    • Ashraf Zeidan
    • Amr Elahwany
    • Mohamed Wael Ragab
    • Omar Zahran
    • Hany Saad

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 75
Population
75 infertile patients
Methods
Group (A) received 2660 mg d-aspartic acid plus 200 mg of ubiquinol plus 10 mg zinc once daily for 3 months. Group (B) received placebo (starch granules) daily for 3 months
Blinding
Open-label
Duration
3 months

Introduction

About 20-30% of cases of infertility are attributed to male factor and males are also contributing to infertility in a further 20%. Idiopathic male subfertility is the commonest cause in most cases. D-aspartic acid (D-Asp) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. The current study is one of the first to evaluate the in vivo supplementation of D-aspartic acid in idiopathic male infertility. Thus, we aimed in the current study to evaluate the in vivo effect of D-aspartic acid, zinc and co-enzyme Q 10 supplementation on different semen parameters and serum testosterone level in idiopathic male infertility.

Methods

A total of 75 infertile patients were recruited from the outpatient andrology clinic from March 2023 to June 2024. The current study was registered at the UMIN clinical registry trials prior to initiating the study (UMIN000050023). Group (A) included 24 infertile patients who received 2660 mg d-aspartic acid plus 200 mg of ubiquinol plus 10 mg zinc once daily for 3 months. Group (B) included 24 infertile patients who received placebo (starch granules) daily for 3 months.

Results

Interestingly, patients in group (A) who received 2660 mg d-aspartic acid plus 200 mg of ubiquinol plus 10 mg zinc once daily for 3 months showed significant improvement in progressive sperm motility after 3 months (10.63 ± 8.64 vs 15.21 ± 12.11, p=0.047). Also, they showed highly significant increase in total testosterone level (5.06 ± 1.74 vs 5.89 ± 1.62, p=0.009).

Conclusions

D-aspartic acid plus ubiquinol plus zinc are promising ingredients that showed good results when administrated once daily to infertile males.

Research Insights

  • Zinc→Improved Progressive Sperm Motility

    patients in group (A) who received 2660 mg d-aspartic acid plus 200 mg of ubiquinol plus 10 mg zinc once daily for 3 months showed significant improvement in progressive sperm motility after 3 months (10.63 ± 8.64 vs 15.21 ± 12.11, p=0.047).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    10 mg/day
  • Zinc→Increased Total Testosterone Level

    Also, they showed highly significant increase in total testosterone level (5.06 ± 1.74 vs 5.89 ± 1.62, p=0.009).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    10 mg/day
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