Evaluation of the Effect of Probiotic Supplementation on Intestinal Barrier Integrity and Epithelial Damage in Colitis Disease: A Systematic Review.

2024-11-27
Nutrition reviews 83(7)

PubMed: 39602817
DOI: 10.1093/nutrit/nuae180

Study Design

Type: Systematic Review
Population: colitis disease
Methods: systematically examine the effects of probiotic use on barrier integrity in colitis disease; systematic search in PubMed, Web of Science, Scopus, and Cochrane databases; 46 studies that met the inclusion criteria were analyzed within the scope of the systematic review

Context

Previous reviews have focused on the effects of probiotics on colitis, but there is a need to understand their impact on barrier integrity and tight junction protein improvement in colitis.

Objective

This study aimed to systematically examine the effects of probiotic use on barrier integrity in colitis disease. This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Data sources

A systematic search in PubMed, Web of Science, Scopus, and Cochrane databases identified 2537 articles.

Data extraction

As a result of the search, 2537 articles were accessed. Study results were summarized descriptively through discussions by intervention conditions, study population, measurement methods, and key findings. The included studies were independently reviewed and all authors reached consensus on the quality and major findings from the included articles. Forty-six studies that met the inclusion criteria were analyzed within the scope of the systematic review.

Results

Although the study primarily utilized probiotics from the Lactobacillaceae family (notably, L casei, L reuteri, L rhamnosus, L plantarum, and L pentosus) and the Bifidobacteriaceae family (notably, B breve, B animalis, and B dentium), other probiotics also demonstrated positive effects on tight junction proteins. These effects are attributed to the production of bioactive and metabolic compounds, as well as short-chain fatty acids, which combat pathogens and reduce anti-inflammatory agents. However, it was observed that the effects of these probiotics on tight junction proteins varied depending on the strain and dose.

Conclusion

The beneficial effects of probiotics on remission in inflammatory bowel disease are well documented. Studies show that probiotics generally improve intestinal barrier function, but factors such as dose, duration, and bacterial species combinations need further clarification. Additionally, comprehensive studies are needed to understand how improved barrier function affects absorption in individuals.

Systematic review registration

PROSPERO registration no. CRD42023452774.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium animalis subsp. lactis BB-12	—	Improved Intestinal Barrier Function	Beneficial	Moderate	View source other probiotics also demonstrated positive effects on tight junction proteins. These effects are attributed to the production of bioactive and metabolic compounds, as well as short-chain fatty acids, which combat pathogens and reduce anti-inflammatory agents.
Bifidobacterium animalis subsp. lactis BB-12	—	Reduced Epithelial Breakdown	Beneficial	Moderate	View source This study aimed to systematically examine the effects of probiotic use on barrier integrity in colitis disease.
Bifidobacterium breve Bb-18	—	Improved Intestinal Barrier Function	Beneficial	Moderate	View source other probiotics also demonstrated positive effects on tight junction proteins. These effects are attributed to the production of bioactive and metabolic compounds, as well as short-chain fatty acids, which combat pathogens and reduce anti-inflammatory agents.
Bifidobacterium breve Bb-18	—	Reduced Epithelial Breakdown	Beneficial	Moderate	View source This study aimed to systematically examine the effects of probiotic use on barrier integrity in colitis disease.