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Exopolysaccharide from Lactobacillus fermentum Lf2 and its functional characterization as a yogurt additive.

  • 2016-11
  • Journal of Dairy Research 83(4)
    • E. C. Ale
    • M. Perezlindo
    • P. Burns
    • Eduardo Tabacman
    • J. Reinheimer
    • A. Binetti


Lactobacillus fermentum Lf2 is a strain which is able to produce high levels (approximately 1 g/l) of crude exopolysaccharide (EPS) when it is grown in optimised conditions. The aim of this work was to characterize the functional aspects of this EPS extract, focusing on its application as a dairy food additive. Our findings are consistent with an EPS extract that acts as moderate immunomodulator, modifying s-IgA and IL-6 levels in the small intestine when added to yogurt and milk, respectively. Furthermore, this EPS extract, in a dose feasible to use as a food additive, provides protection against Salmonella infection in a murine model, thus representing a mode of action to elicit positive health benefits. Besides, it contributes to the rheological characteristics of yogurt, and could function as a food additive with both technological and functional roles, making possible the production of a new functional yogurt with improved texture.

Keywords: Salmonella; Exopolysaccharide; IgA; cytokines; lactic acid bacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentum Lf-33Improved Yogurt TextureBeneficial
Lactobacillus fermentum Lf-33Reduced Risk of Salmonella InfectionBeneficial
Lactobacillus fermentum LF61Improved ImmunomodulationBeneficial
Lactobacillus fermentum LF61Reduced Risk of Salmonella InfectionBeneficial
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