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Exopolysaccharide from Lactobacillus rhamnosus ZFM231 alleviates DSS-induced colitis in mice by regulating gut microbiota.

  • 2022-07-02
  • Journal of the Science of Food and Agriculture 102(15)
    • C. Wan
    • Wen-Wen Qian
    • W. Liu
    • X. Pi
    • Meng Tang
    • Xiao-Lin Wang
    • Q. Gu
    • Ping Li
    • Tao Zhou

Abstract

Background: The exopolysaccharides (EPS) produced by Lactobacillus and other probiotics are associated with many benefits, such as immune regulation, antioxidant properties, antitumor effect, and regulation of intestinal microbe homeostasis. In the present study, the modulatory effect of EPS produced by Lactobacillus rhamnosus ZFM231 on the intestinal flora of mice with inflammatory bowel disease induced by dextran sulfate solution was investigated.

Results: Results indicated that weight loss, colonic length, the disease activity index score and colonic tissue damage in mice were significantly improved by EPS treatment. Compared with the model group, in the EPS-treated group, the diversity of and the composition of gut microbiota at both phylum and genus levels were found to recover to the levels of normal group, indicating the effective modulation on gut microbiota by EPS; short-chain fatty acids, including acetic acid, propionic acid and butyric acid produced by intestinal microbial metabolism, increased significantly; the level of anti-inflammatory factor transforning growth factor-β significantly increased and the level of pro-inflammatory factor tumor necrosis factor-α significantly decreased in the colonic cells of EPS-treated mice.

Conclusion: It is clear that EPS produced by L. rhamnosus ZFM231 could find application in functional foods with the property of anti-ulcerative colitis. The experimental results provide new insights into the probiotic effect of EPS. © 2022 Society of Chemical Industry.

Keywords: DSS-induced colitis; Lactobacillus rhamnosus; exopolysaccharide; gut microbiota; short-chain fatty acid.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosusImproved Colonic LengthBeneficial
Moderate
Lactobacillus rhamnosusImproved Gut Microbiota DiversityBeneficial
Large
Lactobacillus rhamnosusIncreased Anti-Inflammatory Factor (TGF-β)Beneficial
Moderate
Lactobacillus rhamnosusIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Lactobacillus rhamnosusReduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosusReduced Disease Activity ScoreBeneficial
Moderate
Lactobacillus rhamnosusReduced Pro-Inflammatory Factor TNF-αBeneficial
Large
Lactobacillus rhamnosusReduced Tissue Damage from ColitisBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Improved Colonic HealthBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Increased Short-Chain Fatty Acid ProductionBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Body Weight LossBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Inflammation LevelsBeneficial
Large
Lactobacillus rhamnosus DSM33560Restored Microbial DiversityBeneficial
Large
Lactobacillus rhamnosus lysate powderImproved Colonic LengthBeneficial
Moderate
Lactobacillus rhamnosus lysate powderImproved Disease Activity Index ScoreBeneficial
Moderate
Lactobacillus rhamnosus lysate powderImproved Gut Microbiota DiversityBeneficial
Large
Lactobacillus rhamnosus lysate powderIncreased Anti-Inflammatory Factor (TGF-β)Beneficial
Moderate
Lactobacillus rhamnosus lysate powderIncreased Short-Chain Fatty Acid LevelsBeneficial
Moderate
Lactobacillus rhamnosus lysate powderReduced Body WeightBeneficial
Moderate
Lactobacillus rhamnosus lysate powderReduced Tissue Damage from ColitisBeneficial
Moderate
Lactobacillus rhamnosus lysate powderReduced Tumor Necrosis Factor AlphaBeneficial
Moderate

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