Exopolysaccharide-producing Streptococcus thermophilus CRL1190 reduces the inflammatory response caused by Helicobacter pylori.
- 2017-05-30
- Beneficial Microbes 8(3)
- G. Marcial
- J. Villena
- G. Faller
- A. Hensel
- G. F. de Valdez
- PubMed: 28504579
- DOI: 10.3920/BM2016.0186
Abstract
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H. pylori through the reduction of its adhesion and the modulation of the inflammatory response. Therefore, S. thermophilus CRL1190 fermented milk is a good candidate for further in vivo studying of the protective effect of functional food against H. pylori infection and gastric inflammatory damage.
Keywords: S. thermophilus CRL1190; gastritis; inflammation; pathogenic bacteria; probiotic; stomach.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Streptococcus thermophilus PXN 66 | Reduced Inflammatory Response | Beneficial | Moderate |
| Streptococcus thermophilus PXN 66 | Reduced Pathogen Adhesion | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Improved Protection Against Helicobacter pylori | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Reduced Inflammatory Response | Beneficial | Moderate |
| Streptococcus thermophilus SEBiotic | Reduced Pathogen Adhesion | Beneficial | Moderate |
| Streptococcus thermophilus SL-21 | Reduced Inflammatory Response | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Reduced Inflammation Levels | Beneficial | Moderate |
| Streptococcus thermophilus UASt-09 | Reduced Pathogen Adhesion | Beneficial | Moderate |