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Abstract

This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H. pylori through the reduction of its adhesion and the modulation of the inflammatory response. Therefore, S. thermophilus CRL1190 fermented milk is a good candidate for further in vivo studying of the protective effect of functional food against H. pylori infection and gastric inflammatory damage.

Keywords: S. thermophilus CRL1190; gastritis; inflammation; pathogenic bacteria; probiotic; stomach.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Streptococcus thermophilus PXN 66Reduced Inflammatory ResponseBeneficial
Moderate
Streptococcus thermophilus PXN 66Reduced Pathogen AdhesionBeneficial
Moderate
Streptococcus thermophilus SEBioticImproved Protection Against Helicobacter pyloriBeneficial
Moderate
Streptococcus thermophilus SEBioticReduced Inflammatory ResponseBeneficial
Moderate
Streptococcus thermophilus SEBioticReduced Pathogen AdhesionBeneficial
Moderate
Streptococcus thermophilus SL-21Reduced Inflammatory ResponseBeneficial
Moderate
Streptococcus thermophilus UASt-09Reduced Inflammation LevelsBeneficial
Moderate
Streptococcus thermophilus UASt-09Reduced Pathogen AdhesionBeneficial
Moderate

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