Exploring the gut microbiome: probiotics, prebiotics, synbiotics, and postbiotics as key players in human health and disease improvement.
- 2024-06-27
- Food science and biotechnology 33(9)
- PubMed: 39130661
- DOI: 10.1007/s10068-024-01620-1
Study Design
- Type
- Review
- Methods
- This review explores the intricate interaction between the gut microbiome and other organs, and their improvement from disease by prebiotics, probiotics, synbiotics, and postbiotics. Each section of the review is supported by clinical trials.
The human gut microbiome accompanies us from birth, and it is developed and matured by diet, lifestyle, and environmental factors. During aging, the bacterial composition evolves in reciprocal communication with the host's physiological properties. Many diseases are closely related to the gut microbiome, which means the modulation of the gut microbiome can promote the disease targeting remote organs. This review explores the intricate interaction between the gut microbiome and other organs, and their improvement from disease by prebiotics, probiotics, synbiotics, and postbiotics. Each section of the review is supported by clinical trials that substantiate the benefits of modulation the gut microbiome through dietary intervention for improving primary health outcomes across various axes with the gut. In conclusion, the review underscores the significant potential of targeting the gut microbiome for therapeutic and preventative interventions in a wide range of diseases, calling for further research to fully unlock the microbiome's capabilities in enhancing human health.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Lactobacillus reuteri LRE02 | — | Improved Clinical Outcomes | Beneficial | Moderate | View sourcethe modulation of the gut microbiome can promote the disease targeting remote organs |
| Lactobacillus reuteri LRE02 | — | Improved Gut Microbiota Composition | Beneficial | Moderate | View sourcethe review underscores the significant potential of targeting the gut microbiome for therapeutic and preventative interventions in a wide range of diseases |