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Exploring the Science behind Bifidobacterium breve M-16V in Infant Health

  • 2019-07-25
  • Nutrients 11(8)
    • C. B. Wong
    • N. Iwabuchi
    • J. Xiao


Probiotics intervention has been proposed as a feasible preventative approach against adverse health-related complications in infants. Nevertheless, the umbrella concept of probiotics has led to a massive application of probiotics in a range of products for promoting infant health, for which the strain-specificity, safety and efficacy findings associated with a specific probiotics strain are not clearly defined. Bifidobacterium breve M-16V is a commonly used probiotic strain in infants. M-16V has been demonstrated to offer potential in protecting infants from developing the devastating necrotising enterocolitis (NEC) and allergic diseases. This review comprehends the potential beneficial effects of M-16V on infant health particularly in the prevention and treatment of premature birth complications and immune-mediated disorders in infants. Mechanistic studies supporting the use of M-16V implicated that M-16V is capable of promoting early gut microbial colonisation and may be involved in the regulation of immune balance and inflammatory response to protect high-risk infants from NEC and allergies. Summarised information on M-16V has provided conceptual proof of the use of M-16V as a potential probiotics candidate aimed at promoting infant health, particularly in the vulnerable preterm population.

Keywords: Bifidobacterium breve M-16V; clinical efficacy; gut microbiota; infant health; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve M-16VPromotion of Healthy Gut Microbial ColonizationBeneficial
Bifidobacterium breve M-16VReduced Allergic DiseasesBeneficial
Bifidobacterium breve M-16VReduced Risk of Necrotizing EnterocolitisBeneficial

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