Skip to main content

Abstract

Background: Viral infections of the upper airways are the most common cause for absence from work or school, and there is evidence for probiotic efficacy in reducing the incidence and severity of these infections.

Objectives: We aimed to confirm the previously reported beneficial effects of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 against community-acquired common colds and identify a possible mechanism of action.

Methods: In a double-blind study, healthy adults (18-70 years of age) with at least 4 colds during the last 12 months before recruitment were randomly allocated to consume either probiotics (n = 448; total daily dose of 109 CFU with the 2 strains equally represented) or placebo (n = 450) once daily for 12 weeks. Recruitment took place from October to February during 2013-2016 (over 3 cold seasons). The probiotic impact on the severity of the colds (Wisconsin Upper Respiratory Symptom Survey-21) was the primary endpoint, whereas secondary endpoints included the incidence rate and duration of colds and an analysis of immune markers. Mann-Whitney U test and mixed model were used for the analysis of continuous variables and Fisher´s exact test was used for the analysis of categorical endpoints.

Results: Symptom severity was not reduced after intake of the probiotic, despite the positive trend seen in the first season. However, significantly fewer colds were experienced in the probiotic group (mean of 1.24 colds) as compared to the placebo group (mean of 1.36 colds; P = 0.044) for subjects reporting at least 1 cold, the incidence of recurring colds was 30% lower (20.8% vs. 29.8%, respectively; P = 0.055), and the use of analgesics was 18% lower (26.3% vs. 32%, respectively; P = 0.07). After 12 weeks, the change from baseline for IFN-γ differed between the groups (mean difference of -7.01; 95% CI, -14.9 to 0.93; P = 0.045).

Conclusions: Intake of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 can be protective against multiple colds in adults prone to getting colds.This trial was registered at clinicaltrials.gov as NCT02013934.

Keywords: Lacticaseibacillus paracasei; Lactiplantibacillus plantarum; Probi Defendum®; probiotic; respiratory tract infections.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus caseiReduced Analgesic UsageBeneficial
Small
Lacticaseibacillus caseiReduced Cold IncidenceBeneficial
Moderate
Lacticaseibacillus caseiReduced Cold RecurrenceBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Altered IFN-γ LevelsNeutral
Small
Lacticaseibacillus paracasei Lpc-37Reduced Analgesic UsageBeneficial
Small
Lacticaseibacillus paracasei Lpc-37Reduced Cold RecurrenceBeneficial
Moderate
Lacticaseibacillus paracasei Lpc-37Reduced Incidence of Common ColdsBeneficial
Small
Lactiplantibacillus plantarumReduced Analgesic UsageBeneficial
Small
Lactiplantibacillus plantarumReduced Incidence of ColdsBeneficial
Small
Lactiplantibacillus plantarumReduced Incidence of Recurring ColdsBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Improved IFN-γ LevelsBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Reduced Analgesic UsageBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Reduced Frequency of Recurring ColdsBeneficial
Small
Lactiplantibacillus plantarum KABP™-022Reduced Incidence of Community-Acquired ColdsBeneficial
Small
Lactiplantibacillus plantarum KABP™-023Modulated Immune Marker IFN-γBeneficial
Small
Lactiplantibacillus plantarum KABP™-023Reduced Analgesic UsageBeneficial
Small
Lactiplantibacillus plantarum KABP™-023Reduced Cold RecurrenceBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Reduced Incidence of Common ColdsBeneficial
Small
Lactobacillus plantarum HEAL9Altered IFN-γ LevelsNeutral
Small
Lactobacillus plantarum HEAL9Reduced Cold RecurrenceBeneficial
Moderate
Lactobacillus plantarum HEAL9Reduced Incidence of ColdsBeneficial
Small

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.