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Folate intake and the risk of endometrial cancer: A dose-response meta-analysis.

  • 2024-09-20
  • Medicine 103(38)
    • Jiaye Long
    • Du Wang
    • Miyang Yang
    • Yingrong Pang
    • Meiqiong Li
    • Shuxin Qin
    • Kai Cui

Study Design

Type
Meta-Analysis
Sample size
n = 570
Population
379,570 participants and 8660 EC cases
Methods
Thorough search using PubMed, EMBASE, the Cochrane Library, and Web of Science; Stata 14 software used to analyze findings; meta-analysis conducted in accordance with PRISMA guidelines; protocol registered in PROSPERO (CRD42024505943)
Funding
Unclear

Background

The relationship between folate intake and risk of endometrial cancer (EC) is debatable. The goal of this study was to examine the relationship between folate consumption and EC and then conduct a dose-response analysis in accordance with this.

Methods

Up until February 1, 2024, we conducted a thorough search using PubMed, EMBASE, the Cochrane Library, and Web of Science. Stata 14 software was used to analyze the findings of the article. The study protocol was registered in PROSPERO (CRD42024505943), and the meta-analysis was conducted in accordance with PRISMA guidelines.

Results

Nine case-control studies and 6 cohort studies were included, comprising 379,570 participants and 8660 EC cases. The highest level of folate consumption was associated with a 10% reduction in the occurrence of EC (relative risk [RR] = 0.90, 95% confidence intervals I2 = 63.2%) compared to the lowest level of intake. The association exhibited a statistically significant linear trend (P = .231), with a combined RR of 0.974 (95% CI: 0.968-0.981) for each daily intake of 50 µg folate.

Conclusion

Folate intake may reduce the risk of EC.

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