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Abstract

Food-associated Lactiplantibacillus plantarum (Lpb. plantarum) strains, previously classified as Lactobacillus plantarum, are a promising strategy to face intestinal inflammatory diseases. Our study was aimed at clarifying the protective role of food-borne Lpb. plantarum against inflammatory damage by testing the scavenging microbial ability both in selected strains and in co-incubation with normal mucosa intestinal cells (NCM460). Here, we show that Lpb. plantarum endure high levels of induced oxidative stress through partially neutralizing reactive oxygen species (ROS), whereas they elicit their production when co-cultured with NCM460. Moreover, pre-treatment with food-borne Lpb. plantarum significantly reduce pro-inflammatory cytokines IL-17F and IL-23 levels in inflamed NCM460 cells. Our results suggest that food-vehicled Lpb. plantarum strains might reduce inflammatory response in intestinal cells by directly modulating local ROS production and by triggering the IL-23/IL-17 axis with future perspectives on health benefits in the gut derived by the consumption of functional foods enriched with selected strains.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarumNeutralized Reactive Oxygen Species LevelsBeneficial
Moderate
Lactiplantibacillus plantarumReduced Inflammatory Response in Intestinal CellsBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Reduced Inflammatory ResponseBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Reduced Inflammatory Response in Intestinal CellsBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Inflammatory ResponseBeneficial
Moderate
Lactiplantibacillus plantarum LP-01Reduced Reactive Oxygen Species FormationBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Inflammatory ResponseBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Intracellular Reactive Oxygen Species LevelsBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Neutralized Reactive Oxygen SpeciesBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Reduced Inflammatory ResponseBeneficial
Moderate

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