Functions of N-Glycosylation-Related Endoplasmic Reticulum Proteins in the Development and Virulence of Plant Pathogens.
- 2025-11-05
- Journal of fungi (Basel, Switzerland) 11(11)
- Yanxin Wang
- Kaijie Chen
- Yu Zhang
- Zimeng Zhang
- Zi Tao
- Xianfeng Ye
- PubMed: 41295171
- DOI: 10.3390/jof11110791
Study Design
- Type
- Review
N-glycosylation, a crucial eukaryotic post-translational modification, has been extensively studied for its significance in the physiology and virulence processes of plant pathogens over the last decade. This review systematically analyzes the functions of N-glycosylation-related endoplasmic reticulum (ER) proteins in regulating plant pathogen processes, including mycelial growth, conidial development, host penetration as well as colonization, pathogenicity, cell wall integrity and host immune evasion. By modifying the structure and function of target proteins, these ER-localized proteins regulate essential developmental events in pathogens while concurrently mediating interactions between pathogens and plants, influencing pathogens' growth and disease-causing potential. Future research requires the systematic delineation of glycosylation-regulated protein networks by multi-omics integration technologies and the elucidation of their functional processes using molecular genetics methodologies, thereby establishing a robust theoretical foundation for the development of novel biological fungicides.