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Abstract

Certain lactic acid bacteria (LAB) have the capacity to occupy mucosal niches of humans, including the oral cavity, gastrointestinal tract, and vagina. Among commensal, LAB are species of the acidophilus complex, which have proven to be a substantial reservoir for microorganisms with probiotic attributes. Specifically, Lactobacillus gasseri is an autochthonous microorganism which has been evaluated for probiotic activity based on the availability of genome sequence and species-specific adaptation to the human mucosa. Niche-related characteristics of L. gasseri contributing to indigenous colonization include tolerance of low pH environments, resistance to bile salts, and adhesion to the host epithelium. In humans, L. gasseri elicits various health benefits through its antimicrobial activity, bacteriocin production, and immunomodulation of the innate and adaptive systems. The genomic and empirical evidence supporting use of L. gasseri in probiotic applications is substantiated by clinical trial data displaying maintenance of vaginal homeostasis, mitigation of Helicobacter pylori infection, and amelioration of diarrhea.

Keywords: acidophilus complex; autochthonous; bacteriocin; gastrointestinal tract; lactic acid bacteria; microbiota.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriImproved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseriMaintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseriReduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri BNR17Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri BNR17Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri BNR17Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri KS-13Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri KS-13Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri LAC-343Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri LAC-343Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri LBV 150NImproved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri LBV 150NMaintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri LG-36Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri LG-36Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri LQ-36Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri LQ-36Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri SD-5585Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri SD-5585Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Helicobacter pylori ColonizationBeneficial
Moderate
Lactobacillus gasseri UALg-05Improved Diarrhea SymptomsBeneficial
Moderate
Lactobacillus gasseri UALg-05Maintained Vaginal HomeostasisBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Helicobacter pylori ColonizationBeneficial
Moderate

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