Gut Microbiome and Metabolome Alterations in Overweight or Obese Adult Population after Weight-Loss Bifidobacterium breve BBr60 Intervention: A Randomized Controlled Trial.

2024-10-10
International journal of molecular sciences 25(20)

PubMed: 39456659
DOI: 10.3390/ijms252010871

Study Design

Type: Randomized Controlled Trial (RCT)
Population: 75 overweight or obese young adults
Methods: randomly assigned to either a Bifidobacterium breve BBr60 (BBr60) group or a placebo group; both groups received diet guidance and took either BBr60 (1 × 10^10 CFU/day) or a placebo for 12 weeks

Rigorous Journal

Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 overweight or obese young adults, randomly assigned to either a Bifidobacterium breve BBr60 (BBr60) group or a placebo group. Both groups received diet guidance and took either BBr60 (1 × 10¹⁰ CFU/day) or a placebo for 12 weeks. Researchers analyzed body composition, serum glucose, lipids, liver and kidney function, comprehensive metabolome, and intestinal homeostasis before and after the intervention. After 12 weeks, BBr60 significantly reduced weight and BMI compared to pretreatment levels and outperformed the placebo. The BBr60 group also showed improved blood biochemistry, with notably lower fasting blood glucose (FBG) levels than the placebo group (p < 0.05). Additionally, BBr60 influenced vital serum and fecal metabolites related to three amino acid metabolic pathways and regulated the bacteria Dialister, Klebsiella, and Bacteroides, which correlated strongly with serum metabolites. These findings indicate that BBr60 can safely and effectively regulate BMI, body weight, serum glucose, lipids, and liver function markers, which may involve BBr60's impact on key gut bacteria, which influence metabolites related to the valine, leucine, and isoleucine biosynthesis; glycine, serine, and threonine metabolism; and alanine, aspartate, and glutamate metabolism.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium breve BBr60	—	Improved Blood Biochemistry	Beneficial	Moderate	View source The BBr60 group also showed improved blood biochemistry... BBr60 can safely and effectively regulate BMI, body weight, serum glucose, lipids, and liver function markers.
Bifidobacterium breve BBr60	—	Reduced Fasting Blood Glucose Levels	Beneficial	Small	View source The BBr60 group also showed improved blood biochemistry, with notably lower fasting blood glucose (FBG) levels than the placebo group (p < 0.05).