Harnessing the power of the gut microbiome: a review of supplementation diagnosis and therapy for liver cirrhosis.

Abstract

Liver cirrhosis is an end-stage pathological process caused by various chronic liver diseases, whose incidence is increasing and represents a serious public health burden. The onset of liver cirrhosis is related to various factors such as alcohol, autoimmune, steatosis, and viral infections. Recent research suggests that the gut microbiota also participates in the progression of liver cirrhosis and that supplementation with probiotics improves the progression of liver diseases. We have reviewed the latest studies on the mutual influence between the gut microbiota (including bacteria, fungi and virus) and cirrhosis, and summarized the changes in the gut microbiota, the immune and metabolic mechanisms, and the application of gut microbiota in the clinical management, hoping to provide new strategies for the diagnosis and treatment of liver cirrhosis.

Graphical Abstract:

Keywords: Gut microbiota; Gut-liver axis; Liver cirrhosis; Treatment.