Skip to main content

Abstract

Short-term administration of Lactobacillus gasseri CP2305 improves stress-associated symptoms and clinical symptoms in healthy young adults and in patients with irritable bowel syndrome, respectively. We evaluated the efficacy and health benefits of the long-term use of a tablet containing heat-inactivated, washed Lactobacillus gasseri CP2305 (CP2305) in healthy young adults. Sixty Japanese medical students (41 men and 19 women) preparing for the national examination for medical practitioners ingested CP2305-containing or placebo tablets once daily for 24 weeks. Intake of the CP2305 tablet significantly reduced anxiety and sleep disturbance relative to placebo, as quantitated by the Spielberger State-Trait Anxiety Inventory and the Pittsburgh Sleep Quality Index. Single-channel sleep electroencephalograms show that CP2305 significantly shortened sleep latency and wake time after sleep onset and increased the delta power ratio in the first sleep cycle. CP2305 also significantly lowered salivary chromogranin A levels compared with placebo. Furthermore, 16S rRNA gene sequencing of participant feces demonstrated that CP2305 administration attenuated the stress-induced decline of Bifidobacterium spp. and the stress-induced elevation of Streptococcus spp. We conclude that the long-term use of CP2305-containing tablets may improve the mental state, sleep quality, and gut microbiota of healthy adults under stressful conditions.

Keywords: fecal microbiota; healthy young adults; heat-inactivated Lactobacillus gasseri CP2305; mental health; psychobiotics; sleep quality; stress.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus gasseriImproved Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseriImproved Sleep QualityBeneficial
Large
Lactobacillus gasseriReduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseriReduced Salivary Chromogranin A LevelsBeneficial
Moderate
Lactobacillus gasseri KS-13Improved Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseri KS-13Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri KS-13Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri KS-13Reduced Salivary Chromogranin A LevelsBeneficial
Moderate
Lactobacillus gasseri LAC-343Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri LAC-343Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri LAC-343Reduced Salivary Chromogranin A LevelsBeneficial
Moderate
Lactobacillus gasseri LBV 150NImproved Sleep QualityBeneficial
Large
Lactobacillus gasseri LBV 150NReduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri LBV 150NReduced Stress IndicatorsBeneficial
Moderate
Lactobacillus gasseri LBV 150NStabilized Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseri LG-36Improved Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseri LG-36Improved Mental HealthBeneficial
Moderate
Lactobacillus gasseri LG-36Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri LG-36Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri LG-36Reduced Salivary Chromogranin A LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Improved Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseri LQ-36Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri LQ-36Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri LQ-36Reduced Stress BiomarkersBeneficial
Moderate
Lactobacillus gasseri SD-5585Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus gasseri SD-5585Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri SD-5585Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri SD-5585Reduced Salivary Chromogranin A LevelsBeneficial
Moderate
Lactobacillus gasseri UALg-05Attenuated Stress-Induced Changes in Gut MicrobiotaBeneficial
Moderate
Lactobacillus gasseri UALg-05Improved Sleep QualityBeneficial
Large
Lactobacillus gasseri UALg-05Reduced Anxiety LevelsBeneficial
Moderate
Lactobacillus gasseri UALg-05Reduced Salivary Chromogranin A LevelsBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.