Heavy Metal-Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection.

2025-03-14
Biosensors 15(3)

PubMed: 40136985
DOI: 10.3390/bios15030188

Study Design

Type: Review
Methods: comprehensive analysis of the complex interaction between heavy metals (HMs) and the gut microbiota, adopting a bidirectional approach

This study provides a comprehensive analysis of the complex interaction between heavy metals (HMs) and the gut microbiota, adopting a bidirectional approach that explores both the influence of HMs on the gut microbiota populations and the potential role of probiotics in modulating these changes. By examining these interconnected aspects, the study aims to offer a deeper understanding of how HMs disrupt microbial balance and how probiotic interventions may mitigate or reverse these effects, promoting detoxification processes and overall gut health. In addition, the review highlights innovative tools, such as biosensors, for the rapid, precise, and non-invasive detection of HMs in urine. These advanced technologies enable the real-time monitoring of the effectiveness of probiotic-based interventions, offering critical insights into their role in promoting the elimination of HMs from the body and improving detoxification.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium bifidum Rosell-71	—	Enhanced Detoxification	Beneficial	Moderate	View source These advanced technologies enable the real-time monitoring of the effectiveness of probiotic-based interventions, offering critical insights into their role in promoting the elimination of HMs from the body and improving detoxification.
Bifidobacterium bifidum Rosell-71	—	Improved Gut Microbiota Balance	Beneficial	Moderate	View source the potential role of probiotics in modulating these changes. By examining these interconnected aspects, the study aims to offer a deeper understanding of how HMs disrupt microbial balance and how probiotic interventions may mitigate or reverse these effects, promoting detoxification processes and overall gut health.