Study Design
- Population
- 24 adult male albino rats
- Methods
- Rats subjected to CUMS Model for 21 days, then clove oil applied intranasally (0.02 mL/kg) daily for 14 days
- Duration
- 14 days
- Funding
- Unclear
Background
depression is the most widespread psychiatric disorder, making it the fourth leading cause of death among adults. The olfactory system is a component of the limbic system. Repeated exposure to stressful events has been reported to affect emotions and olfactory perception. Clove oil is an essential oil that exhibits immunomodulatory properties and is used in the recovery of olfactory dysfunctions during the COVID-19 outbreak.Aim
Detect the potential hazards of stress-induced depression on the olfactory bulbs and investigate the possible role of clove oil in ameliorating these effects.Material and methods
Twenty-four adult male albino rats were divided equally into three groups: a control group (I), Group (II): depression group, rats were subjected to CUMS Model for 21 days, then were subdivided equally into group (IIa): rats were sacrificed after 21 days, and group (IIb): rats were left for spontaneous recovery for 14 days, then sacrificed. Group (III): rats were subjected to CUMS Model for 21 days, then clove was applied intranasally (0.02 mL/kg) daily for 14 days, then sacrificed. Olfactory bulb specimens were examined by light microscopy. The depression altered the normal tissue morphology of the bulb; Glomeruli appeared shrunken in the glomerular layer. Mitral cells appeared fewer in number, with deeply stained nuclei. The granule cells were aggregated with areas of vacuolated neuropil. Clove oil group restored the normal architecture of the olfactory bulb.Conclusion
Clove oil has an ameliorating effect on the injury of the olfactory bulb in the depression induced animal model of Albino rats.
Research Insights
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