HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19.
- 2021-10-01
- Acta bio-medica : Atenei Parmensis 92(S6)
- Giorgio Ciprandi
- Luisa Maria Bellussi
- Valerio Damiani
- Desiderio Passali
- PubMed: 34739475
- DOI: 10.23750/abm.v92is6.12111
Study Design
- Type
- Review
The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in pathogenic mechanisms induced by SARS-CoV-2. As HMGB1 is antagonized by glycyrrhizin, this substance could be potentially useful as ancillary treatment in COVID-19.