Bifidobacterium animalis subsp. lactis BPL1™ and Its Lipoteichoic Acid Modulate Longevity and Improve Age/Stress-Related Behaviors in Caenorhabditis elegans.
- 2023-12-13
- Antioxidants (Basel, Switzerland) 12(12)
- PubMed: 38136226
- DOI: 10.3390/antiox12122107
Life expectancy has increased globally in recent decades, driving interest in maintaining a healthy life that includes preservation of physical and mental abilities, particularly in elderly people. The gut microbiome becomes increasingly perturbed with aging so the use of probiotics can be a strategy for maintaining a balanced gut microbiome. A previous report showed that Bifidobacterium animalis subsp. lactis BPL1™ induces through its lipoteichoic acid (LTA) fat reduction activities via the insulin/IGF-1 signaling pathway. Here, we have delved into the mechanism of action, eliminating alternative pathways as putative mechanisms. Furthermore, we have identified that BPL1™, its heat treated form (BPL1™ HT) and its LTA prolong longevity in Caenorhabditis elegans (C. elegans) in an insulin/IGF-1-dependent mechanism, and its consumption improves the oxidative stress response, gut permeability and protection against pathogenic infections. Furthermore, positive effects on C. elegans stress-related behaviors and in the Alzheimer's Disease model were found, highlighting the potential of the strain in improving the cognitive functions and proteotoxicity in the nematode. These results indicate the pivotal role of the IGF-1 pathway in the activity of the strain and pave the way for potential applications of BPL1™, BPL1™ HT and its LTA in the field of longevity and age-related markers.
Research Insights
| Supplement | Dose | Health Outcome | Effect Type | Effect Size | Source |
|---|---|---|---|---|---|
| Bifidobacterium animalis subsp. lactis BPL1 | — | Improved Cognitive Function | Beneficial | Small | View sourcehighlighting the potential of the strain in improving the cognitive functions |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Improved Gut Barrier Function | Beneficial | Moderate | View sourceits consumption improves ... gut permeability |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Improved Oxidative Stress Resistance | Beneficial | Moderate | View sourceits consumption improves the oxidative stress response |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Improved Resistance to Infections | Beneficial | Moderate | View sourceprotection against pathogenic infections |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Improved Stress-Related Behavior | Beneficial | Small | View sourcepositive effects on C. elegans stress-related behaviors |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Increased Longevity | Beneficial | Moderate | View sourceBPL1™, its heat treated form (BPL1™ HT) and its LTA prolong longevity in Caenorhabditis elegans |
| Bifidobacterium animalis subsp. lactis BPL1 | — | Reduced Proteotoxicity | Beneficial | Small | View sourceand proteotoxicity in the nematode |