TY-S01 Prevents Loperamide-Induced Constipation by Modulating Gut Microbiota and Its Metabolites in Mice.

2022-06-29
Frontiers in nutrition 9
- Tian Tang
- Jing Wang
- Yuanyuan Jiang
- Xu Zhu
- Zhen Zhang
- Yuying Wang
- Xi Shu
- Yadan Deng
- Feng Zhang

PubMed: 35845767
DOI: 10.3389/fnut.2022.890314

Probiotics have received widespread attention as a healthy ingredient. The preventive effect of Bifidobacterium lactis TY-S01 on loperamide-induced constipation in mice was investigated in this study. TY-S01 accelerated the peristalsis of intestine, maintained the humidity of faeces, and prevented the destruction of gut barrier. TY-S01 also maintained the 5-HT, MTL and SP at normal levels in constipated mice. Simultaneously, TY-S01 up-regulated the mRNA expressions of 5-HT₄R, SERT, and MUC-2, while down-regulated the mRNA expressions of pro-inflammatory genes remarkably. The levels of short-chain fatty acids in the feces of constipated mice were also increased because of the intervention with TY-S01. Moreover, TY-S01 prevented gut microbiological dysbiosis in constipated mice. Spearman's correlation analysis revealed that there was an obvious association between metabolic biomarkers and gut microbiota. In summary, TY-S01 regulated gut microbiota and the production of intestinal metabolites to prevent loperamide-induced constipation.

Research Insights

Supplement	Health Outcome	Effect Type	Effect Size
Bifidobacterium lactis	Improved Constipation	Beneficial	Moderate
Bifidobacterium lactis	Improved Gut Barrier Function	Beneficial	Moderate
Bifidobacterium lactis	Improved Gut Microbiota Composition	Beneficial	Moderate
Bifidobacterium lactis	Increased Short-Chain Fatty Acid Production	Beneficial	Moderate
Bifidobacterium lactis	Reduced Gut Inflammation	Beneficial	Moderate