Streptococcus salivarius and Ligilactobacillus salivarius: Paragons of Probiotic Potential and Reservoirs of Novel Antimicrobials.
- 2025-02-28
- Microorganisms 13(3)
- McKinley D Williams
- Leif Smith
- PubMed: 40142448
- DOI: 10.3390/microorganisms13030555
Study Design
- Type
- Review
This review highlights several basic problems associated with bacterial drug resistance, including the decreasing efficacy of commercially available antimicrobials as well as the related problem of microbiome irregularity and dysbiosis. The article explains that this present situation is addressable through LAB species, such as Streptococcus salivarius and Ligilactobacillus salivarius, which are well established synthesizers of both broad- and narrow-spectrum antimicrobials. The sheer number of antimicrobials produced by LAB species and the breadth of their biological effects, both in terms of their bacteriostatic/bactericidal abilities and their immunomodulation, make them prime candidates for new probiotics and antibiotics. Given the ease with which several of the molecules can be biochemically engineered and the fact that many of these compounds target evolutionarily constrained target sites, it seems apparent that these compounds and their producing organisms ought to be looked at as the next generation of robust dual action symbiotic drugs.
Research Insights
consumption of Lactobacillus salivarius CRL 1328 was associated with a reduction in potentially harmful intestinal bacteria and an increase in beneficial lactobacilli
- Effect
- Beneficial
- Effect size
- Moderate
the study noted immunomodulatory effects, including changes consistent with improved host defense
- Effect
- Beneficial
- Effect size
- Small
Lactobacillus salivarius UCC118 consumption was associated with a reduction in gastrointestinal symptoms
- Effect
- Beneficial
- Effect size
- Small
Lactobacillus salivarius UCC118 consumption was associated with a reduction in gastrointestinal symptoms
- Effect
- Beneficial
- Effect size
- Small