Skip to main content

Identification of a Novel Strain Lactobacillus Reuteri and Anti-Obesity Effect through Metabolite Indole-3-Carboxaldehyde in Diet-Induced Obese Mice.

  • 2023-02-14
  • Journal of Agricultural and Food Chemistry 71(7)
    • Shuhua Shan
    • Qinqin Qiao
    • Ruopeng Yin
    • Lizhen Zhang
    • Jiangying Shi
    • Wenjing Zhao
    • Jiaqi Zhou
    • Zhuoyu Li

Abstract

The potentially beneficial effects of probiotics in the treatment of obesity have been generally demonstrated. In the present study, a new strain of Lactobacillus reuteri SY523 (L. reuteri SY523) with an anti-obesity effect was isolated from the fecal microbiota of diet-induced obese mice. Untargeted metabolomics analysis of mice serum showed that the significantly differential metabolite indole-3-carboxaldehyde (3-IAId) was markedly elevated in the L. reuteri SY523-treated group, and interestingly, the abundance of 3-IAId was significantly negatively associated with obesity-related indicators. As expected, in the HepG2 cell induced by free fatty acids, the potential activity of 3-IAId in restraining lipid deposition was verified. Further, we found that 3-IAId was involved in the anti-obesity effect of L. reuteri SY523 mainly via regulating the cGMP/cAMP signaling pathway. The highlight of this study lies in clarifying the pivotal role of metabolite 3-IAId in the anti-obesity effect induced by L. reuteri SY523, which is conducive to the development of probiotics for anti-obesity agents.

Keywords: DIO mice; Lactobacillus reuteri SY523; anti-obesity; indole-3-carboxaldehyde.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteri LRE02Reduced Lipid DepositionBeneficial
Large
Lactobacillus reuteri LRE02Reduced ObesityBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.