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Identification of a Novel Strain Lactobacillus Reuteri and Anti-Obesity Effect through Metabolite Indole-3-Carboxaldehyde in Diet-Induced Obese Mice.

  • 2023-02-14
  • Journal of Agricultural and Food Chemistry 71(7)
    • Shuhua Shan
    • Qinqin Qiao
    • Ruopeng Yin
    • Lizhen Zhang
    • Jiangying Shi
    • Wenjing Zhao
    • Jiaqi Zhou
    • Zhuoyu Li


The potentially beneficial effects of probiotics in the treatment of obesity have been generally demonstrated. In the present study, a new strain of Lactobacillus reuteri SY523 (L. reuteri SY523) with an anti-obesity effect was isolated from the fecal microbiota of diet-induced obese mice. Untargeted metabolomics analysis of mice serum showed that the significantly differential metabolite indole-3-carboxaldehyde (3-IAId) was markedly elevated in the L. reuteri SY523-treated group, and interestingly, the abundance of 3-IAId was significantly negatively associated with obesity-related indicators. As expected, in the HepG2 cell induced by free fatty acids, the potential activity of 3-IAId in restraining lipid deposition was verified. Further, we found that 3-IAId was involved in the anti-obesity effect of L. reuteri SY523 mainly via regulating the cGMP/cAMP signaling pathway. The highlight of this study lies in clarifying the pivotal role of metabolite 3-IAId in the anti-obesity effect induced by L. reuteri SY523, which is conducive to the development of probiotics for anti-obesity agents.

Keywords: DIO mice; Lactobacillus reuteri SY523; anti-obesity; indole-3-carboxaldehyde.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteri LRE02Reduced Lipid DepositionBeneficial
Lactobacillus reuteri LRE02Reduced ObesityBeneficial

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