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Abstract

The present study investigated the immunomodulating activity of Lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic Escherichia coli O157:H7-infected BALB/c mice. Mice were given L. paracasei subsp. paracasei NTU 101 (10(8) colony-forming units) for 7 days, before and after the challenge with E. coli O157:H7. Feeding Lactobacillus for 7 days resulted in an increased postchallenge weight gain and lower cumulative morbidity rates. We observed the upregulation of dendritic cells, helper T cell activation, and antibody production in post- and pretreated mice, compared with untreated mice in the E. coli O157:H7 infection group. Moreover, Lactobacillus can down-regulate the expression of toll-like receptors (TLRs) on macrophages and proinflammatory cytokines, and chemokines in the post- or prefeeding mice induce by E. coli O157:H7 infection. These results demonstrated the inhibition of inflammation among the mice in the pretreated group than in the post-treated group by modulating their immune response. These findings suggest that L. paracasei subsp. paracasei NTU 101 may be an effective candidate for use as a probiotic in the prevention of infection caused by E. coli O157:H7 in humans.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei subsp. paracasei UALpc-04Improved Immune ResponseBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALpc-04Increased Body WeightBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Cumulative Morbidity RateBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALpc-04Reduced Inflammation LevelsBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Enhanced Antibody ProductionBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Increased Dendritic Cell ActivationBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Increased Helper T Cell ActivationBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Increased Weight Gain Post-ChallengeBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Cumulative Morbidity RatesBeneficial
Moderate
Lactobacillus paracasei subsp. paracasei UALs-04Reduced InflammationBeneficial
Large
Lactobacillus paracasei subsp. paracasei UALs-04Reduced Toll-like Receptor Expression in MacrophagesBeneficial
Moderate

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