Immunomodulating compounds in Basidiomycetes.
- 2013
- Journal of clinical biochemistry and nutrition 52(3)
- Masashi Mizuno
- Yosuke Nishitani
- PubMed: 23704809
- DOI: 10.3164/jcbn.13-3
Study Design
- Type
- Review
Mushrooms are distinguished as important food containing immunomodulating and anticancer agents. These compounds belong mostly to polysaccharides especially β-d-glucans. Among them, β-1,3-glucan with side chain β-1,6-glucose residues have more important roles in immunomodulating and antitumor activities. In this review, we have introduced polysaccharide mainly from Lentinula edodes and Agaricus blazei Murill with immunomodulating and antitumor activities. In addition, the mechanism of activation of immune response and signal cascade are also reviewed.