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Abstract

The immune stimulation induced by Lactobacillus rhamnosus CRL1505 (Lr05) and L. rhamnosus CRL1506 (Lr06) on the resistance to infection with an intestinal pathogen (Salmonella typhimurium) and a respiratory pathogen (Streptococcus pneumoniae) was studied in swiss-albine mice experimental models. The cytokine profiles that induced the innate and specific immune response in both infectious processes were investigated. Both strains were able to improve resistance against the intestinal pathogen. Only Lr05 was able to induce a significant decrease in the number of S. pneumoniae in the lung, prevent its dissemination into the blood and induce a significant increase in Th1 (INF-gamma) and Th2 (IL-6, IL-4 and IL-10) cytokine levels in the bronchoalveolar lavages (BAL). The changes in the cytokines profiles in BAL were associated with an increase in the number and activity of phagocytic cells and with the increase in specific antibodies in serum and BAL, which would explain the increased resistance to the challenge. The administration of Lr06 did not induce significant effects at the respiratory mucosal level. The results described in the present paper showed that certain LAB strains can share certain functional properties, although some of them can perform a functional role better than others, so that it is important to perform careful studies on specific strains, according to their therapeutic use.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus CLR1505Enhanced Mucosal Immune ResponseBeneficial
Large
Lactobacillus rhamnosus CLR1505Enhanced Resistance to Streptococcus Pneumoniae InfectionBeneficial
Large
Lactobacillus rhamnosus CLR1505Improved Intestinal Resistance to Salmonella TyphimuriumBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Enhanced Respiratory Resistance to InfectionBeneficial
Large
Lactobacillus rhamnosus CRL 1505Improved Resistance to Intestinal PathogensBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Prevention of Bloodstream Pathogen DisseminationBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Reduced Respiratory Pathogen LoadBeneficial
Large
Lactobacillus rhamnosus LR05Enhanced Resistance to Streptococcus Pneumoniae InfectionBeneficial
Large
Lactobacillus rhamnosus LR05Improved Intestinal Resistance to Salmonella TyphimuriumBeneficial
Moderate
Lactobacillus rhamnosus LR06Improved Intestinal Resistance to Salmonella TyphimuriumBeneficial
Moderate
Lactobacillus rhamnosus LR06Neutral Effect on Respiratory Infections Caused by Streptococcus PneumoniaeNeutral
Small
Lactobacillus rhamnosus LRa05Improved Resistance to Foodborne PathogensBeneficial
Large
Lactobacillus rhamnosus LRa05Reduced Streptococcus pneumoniae in LungBeneficial
Large

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