Skip to main content

Immunomodulatory and Antioxidant Properties of a Novel Potential Probiotic Bacillus clausii CSI08

  • 2023-01-18
  • Microorganisms 11(2)
    • E. Khokhlova
    • J. Colom
    • A. Simon
    • S. Mazhar
    • Guillermo Garcia-Lainez
    • S. Llopis
    • Núria González
    • María Enrique-López
    • Beatriz Alvarez
    • P. Martorell
    • M. Tortajada
    • J. Deaton
    • K. Rea

Abstract

Spore-forming bacteria of the Bacillus genus have demonstrated potential as probiotics for human use. Bacillus clausii have been recognized as efficacious and safe agents for preventing and treating diarrhea in children and adults, with pronounced immunomodulatory properties during several in vitro and clinical studies. Herein, we characterize the novel strain of B. clausii CSI08 (Munispore®) for probiotic attributes including resistance to gastric acid and bile salts, the ability to suppress the growth of human pathogens, the capacity to assimilate wide range of carbohydrates and to produce potentially beneficial enzymes. Both spores and vegetative cells of this strain were able to adhere to a mucous-producing intestinal cell line and to attenuate the LPS- and Poly I:C-triggered pro-inflammatory cytokine gene expression in HT-29 intestinal cell line. Vegetative cells of B. clausii CSI08 were also able to elicit a robust immune response in U937-derived macrophages. Furthermore, B. clausii CSI08 demonstrated cytoprotective effects in in vitro cell culture and in vivo C. elegans models of oxidative stress. Taken together, these beneficial properties provide strong evidence for B. clausii CSI08 as a promising potential probiotic.

Keywords: Bacillus clausii; adherence; antioxidant; immunomodulation; spore-based probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bacillus clausiiActivated Immune ResponseBeneficial
Moderate
Bacillus clausiiImproved Cytoprotection During Oxidative StressBeneficial
Large
Bacillus clausiiImproved ImmunomodulationBeneficial
Moderate
Bacillus clausiiImproved Intestinal Cell AdhesionBeneficial
Moderate
Bacillus clausiiReduced Proinflammatory Cytokine ExpressionBeneficial
Moderate
Bacillus clausiiSuppressed Pathogenic GrowthBeneficial
Moderate
Bacillus clausii SNZ-1971Enhanced Immune Response in MacrophagesBeneficial
Moderate
Bacillus clausii SNZ-1971Improved Cytoprotection During Oxidative StressBeneficial
Large
Bacillus clausii SNZ-1971Reduced Proinflammatory Cytokine ExpressionBeneficial
Moderate

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.