Skip to main content
Supplement Research and Comparison WebsiteBest Price GuaranteeAbout Us
Supplement Research and Comparison Website

Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt medium.

  • 2008-02-10
  • International Journal of Food Microbiology 121(3)
    • S. Masuda
    • H. Yamaguchi
    • T. Kurokawa
    • T. Shirakami
    • R. Tsuji
    • I. Nishimura

Abstract

A halophilic lactic acid bacterium, Tetragenococcus halophilus, was found to possess an immunomodulatory activity that promotes T helper type 1 (Th1) immunity in addition to its important roles in soy sauce brewing. Strain Th221 was selected from 151 strains isolated from soy sauce (shoyu) moromi, since it induced strong interleukin (IL)-12 production by mouse peritoneal macrophages in vitro. The relationship between the salt concentration in the medium and the IL-12 production-inducing activity of this strain was investigated, and the activity was found to be strong when the bacteria were grown in medium containing > or =10% (w/v) salt. The Th1-promoting activity was also manifested in an in vivo mouse study, since Th1-dependant contact sensitivity was augmented and Th2 immunity, as evaluated by specific immunoglobulin E production, was suppressed following oral ingestion of Th221. Based on these findings, Th221 administration may be useful for improving allergic symptoms.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Tetragenococcus halophilus strain YK-1Improved Th1 ImmunityBeneficial
Moderate
Tetragenococcus halophilus strain YK-1Increased Interleukin-12 ProductionBeneficial
Large
Tetragenococcus halophilus strain YK-1Increased Th1-Dependent Contact SensitivityBeneficial
Moderate
Tetragenococcus halophilus strain YK-1Reduced Allergic SymptomsBeneficial
Moderate
Tetragenococcus halophilus strain YK-1Reduced Th2 ImmunityBeneficial
Moderate
⬆ Back to top
Unsubscribe anytime. See our Privacy Policy.
Pillser
Supplement Research and Comparison Website: evidence-based information about supplements, their benefits, potential risks, and their efficacy.

Join Our Community

Statements on this website have not been reviewed by the U.S. Food and Drug Administration. These products are not meant to diagnose, treat, cure, or prevent any disease. The information here is not a replacement for personal medical advice.