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Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

  • 2019-03-29
  • BMC Complementary and Alternative Medicine 19(1)
    • Su-Jin Jung
    • Eun-Soo Jung
    • Eun‐Kyung Choi
    • H. Sin
    • Ki-Chan Ha
    • S. Chae


Background: Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its efficacy in enhancing the immune system and to evaluate its safety in healthy adults.

Methods: Healthy adults were divided into the intervention group (n = 39), who were given 1.68 g/day of CBG-CS-2 in capsules, and the control group (n = 40) for 8 weeks. The activities of natural killer (NK) cells and serum levels of monocyte-derived mediators were assessed initially for a baseline measurement and after 8 wks.

Results: The CBG-CS-2 group showed a significant 38.8 ± 17.6% enhancement from the baseline of NK cell cytotoxic activity relative to the placebo group after the administration of the capsules for 8 wks. (P < 0.019).

Conclusion: The results suggest that the immune system functions well with CBG-CS-2 supplementation, perhaps with less accompanying inflammation. Thus, CBG-CS-2 is safe and effective for enhancing cell-mediated immunity in healthy adults.

Trial registration: This study was registered at Clinical ( [NCT 02814617]( 02814617 "See in") ).

Trial registration: NCT02814617.

Keywords: Cordyceps; Immune; Mycelium culture; Natural killer (NK) cells; Paecilomyces hepiali.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Paecilomyces hepialiEnhanced Cell-Mediated ImmunityBeneficial
Paecilomyces hepialiEnhanced Natural Killer Cell ActivityBeneficial

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