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Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

  • 2020-07-31
  • Nutrients 12(8)
    • L. M. Rocha-Ramírez
    • Beatriz Hernández-Ochoa
    • S. Gómez-Manzo
    • J. Marcial-Quino
    • N. Cárdenas-Rodríguez
    • S. Centeno-Leija
    • M. García‐Garibay


Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed Lactobacillus casei IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against Salmonella typhimurium, Escherichia coli and Staphylococcus aureus. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed L. casei IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed L. casei IMAU60214 is a potential candidate for regulating the immune function of macrophages.

Keywords: Lactobacillus; burst respiratory; children; cytokines; immunity; macrophage; malnourished; phagocytosis; probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus casei R0215Improved Immune FunctionBeneficial
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