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Impact of Vitamin D3 on Postorthodontic Treatment Stability: A Randomized Controlled Trial.

  • 2025-03-05
  • The journal of contemporary dental practice 25(12)
    • Thrivikhraman Kothandaraman
    • Prema Anbarasu
    • Sp Saravana Dinesh
    • Saravana Kumar Subramanian
    • Gabriel Eisenhuth
    • Sebastian Eisenhuth
    • Claudia Eisenhuth

Study Design

Type
Randomized Controlled Trial (RCT)
Population
Patients aged 15-30 years with dental malocclusion and moderate crowding in the lower arch (Little's irregularity score of 4-6)
Methods
Randomly split into experimental and control groups; vitamin D3 injection delivered to experimental group and placebo injection with 0.9% normal saline mixed with 2% lignocaine to control group; 14 days after injection, lower archwires removed
Duration
3 months

Aim

This study aims to clinically evaluate whether the local administration of vitamin D3 enhances postorthodontic tooth stability over a period of 3 months immediately after debonding.

Materials and methods

Patients aged 15-30 years with dental malocclusion and moderate crowding in the lower arch (Little's irregularity score of 4-6) were selected and randomly split into the experimental and the control groups. After complete alignment and leveling, vitamin D3 injection was delivered to the experimental group and the control group was given a placebo injection with 0.9% normal saline mixed with 2% lignocaine. Fourteen days after the injection, the lower archwires were removed from the control and experimental groups.

Results

Relapse was significantly higher in control than in the experimental group at all-time intervals. Statistically significant values of relapse were observed at T2 and T3 intervals between the two groups, with greater relapse in the control group than in the experimental group. Inter-canine width, arch perimeter, and intermolar width showed mild changes over 3-month period, but there were no significant differences between the two groups.

Conclusion

Relapse was seen in both the control and the experimental in the first 4 weeks of the study. Still, the control group showed a greater relapse rate in the following 8th week and 12th week when compared to the experimental group. How to cite this article: Kothandaraman T, Anbarasu P, Dinesh SPS, et al. Impact of Vitamin D3 on Postorthodontic Treatment Stability: A Randomized Controlled Trial. J Contemp Dent Pract 2024;25(12):1156-1161.

Research Insights

  • Vitamin D3→Reduced Arch Perimeter Change

    Inter-canine width, arch perimeter, and intermolar width showed mild changes over 3-month period, but there were no significant differences between the two groups.

    Effect
    Neutral
    Effect size
    Small
  • Vitamin D3→Reduced Inter-canine Width

    Inter-canine width, arch perimeter, and intermolar width showed mild changes over 3-month period, but there were no significant differences between the two groups.

    Effect
    Neutral
    Effect size
    Small
  • Vitamin D3→Reduced Intermolar Width Change

    Inter-canine width, arch perimeter, and intermolar width showed mild changes over 3-month period, but there were no significant differences between the two groups.

    Effect
    Neutral
    Effect size
    Small
  • Vitamin D3→Reduced Orthodontic Relapse

    Relapse was significantly higher in control than in the experimental group at all-time intervals. Statistically significant values of relapse were observed at T2 and T3 intervals between the two groups, with greater relapse in the control group than in the experimental group.

    Effect
    Beneficial
    Effect size
    Moderate
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