- 2026-03
- Nutrition, metabolism, and cardiovascular diseases : NMCD 36(3)
- Alessandro Di Minno
- Maria Vittoria Morone
- Marcello Cordara
- Daniele Giuseppe Buccato
- Lorenza Francesca De Lellis
- Hammad Ullah
- Roberto Piccinocchi
- Danaé S Larsen
- Alessandra Baldi
- Gaetano Piccinocchi
- Xiang Xiao
- Roberto Sacchi
- Maria Daglia
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 114
- Population
- 114 Participants (18-70 years) with TC levels 200-239 mg/dL and LDL-C <159 mg/dL
- Methods
- Randomised into three groups to receive for 90 days the lowest dose of the food supplement, the highest dose, or placebo
- Duration
- 90 days
- Funding
- Unclear
Background and aims
We have evaluated the efficacy and tolerability of two food supplements (FS) containing flavonoids (naringin and hesperidin); same doses of B3, B6, B9 and B12 vitamins, and two different doses of a blend of Mentha spicata leaf extract and Amaranthus caudatus seed flour, in subjects with borderline high total (TC) and low-density lipoprotein cholesterol (LDL-C) levels.Methods and results
114 Participants (18-70 years) with TC levels 200-239 mg/dL, (5.18-6.19 mmol/L) and LDL-C (<159 mg/dL) were randomised into three groups to receive for 90 days the lowest (n = 38, Treatment A), the highest dose of the FS (n = 38 - Treatment B), or placebo (n = 38). Treatment B was associated with a significant reduction in LDL-C (∼31.5 mg/dL;-22%) and TC (∼19.5 mg/dL; -9%), along with an increase in high-density lipoprotein cholesterol (HDL-C). The greater efficacy of Treatment B containing the highest dose of vegetable extracts is likely attributable to its higher M. spicata extract content, as judged by high-resolution mass spectrometry analysis of the preparation.Conclusion
The combination of different FS ingredients with different mechanisms of action can be a valuable strategy for improving lipid profiles in subjects with borderline high TC and LDL-C levels.