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Abstract

Fifteen lactose malabsorbers were studied to evaluate the effects of consumption of milk containing different strains of Bifidobacterium longum on lactose digestion. Influences of different growth substrates, bile sensitivity, and lactose transport on lactose digestion by bifidobacteria were also investigated. Lactose malabsorption was determined by measuring breath hydrogen excretion of subjects fed four different test milks (three of which contained 5 x 10(8) cfu/ml of B. longum) on 4 different d using a randomized, double-blinded trial. Test milks included 1) 400 ml of lowfat milk (control), 2) 400 ml of milk containing B. longum B6 that had been grown with lactose, 3) 400 ml of milk containing B. longum B6 grown with lactose plus glucose, or 4) 400 ml of milk containing B. longum ATCC 15708 grown with lactose. beta-Galactosidase activity was highest in milk containing B6 grown with lactose but was extremely low in milk containing B6 grown with lactose and glucose. Consumption of milk containing B6 grown with lactose resulted in significantly less hydrogen production and flatulence than occurring after consumption of control milk or the milk containing B6 grown with both lactose and glucose. Hydrogen production after ingestion of 15708 was also significantly lower than hydrogen production after ingestion of the control milk. We concluded that milks containing B. longum might reduce breath hydrogen response and symptoms from lactose malabsorption when the culture is grown in a medium containing only lactose to induce a higher beta-galactosidase level and increase rate of lactose uptake.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium lactis/longumImproved Lactose DigestionBeneficial
Large
Bifidobacterium lactis/longumReduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum B1-05Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum B1-05Reduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum B1-05Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum BI-05Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum BL03Reduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum HA-135Reduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum HA-135Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum iVE-15Reduced FlatulenceBeneficial
Moderate
Bifidobacterium longum KABP-042Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum KABP-042Reduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum KABP-042Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum MM-2Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum MM-2Reduced Gastrointestinal SymptomsBeneficial
Large
Bifidobacterium longum Rosell-175Increased Beta-Galactosidase ActivityBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum Rosell-175 MEReduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum SD-5588Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum SD-5588Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum subsp. longumImproved Lactose DigestionBeneficial
Large
Bifidobacterium longum subsp. longumReduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum subsp. longum 35624Improved Lactose DigestionBeneficial
Large
Bifidobacterium longum subsp. longum 35624Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum subsp. longum UABI-14Reduced Symptoms of Lactose MalabsorptionBeneficial
Large
Bifidobacterium longum UABl-14Reduced Breath Hydrogen ProductionBeneficial
Large
Bifidobacterium longum UABl-14Reduced Symptoms of Lactose MalabsorptionBeneficial
Large

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