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Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study.

  • 2008-09-12
  • Journal of Clinical Periodontology 35(10)
    • H. Shimauchi
    • G. Mayanagi
    • S. Nakaya
    • Maiko Minamibuchi
    • Yasuhiro Ito
    • K. Yamaki
    • H. Hirata

Abstract

Aim: This randomized clinical study was designed to evaluate the effect of probiotic intervention using lactobacilli on the periodontal condition of volunteers without severe periodontitis.

Material and methods: Freeze-dried Lactobacillus salivarius WB21 (WB21)-containing tablets or a placebo were given to volunteers in a double-blind randomized study. A total of 66 volunteers were finally enrolled and randomly assigned to receive tablets containing WB21 (6.7 x 10(8) CFU) with xylitol or xylitol alone (placebo) three times a day for 8 weeks. Periodontal clinical parameters and whole saliva samples were obtained at baseline (BL), 4 weeks, and the end of the interventional period (8 weeks). Salivary lactoferrin (Lf) levels were measured by enzyme-linked immunosorbent assay. Lactobacilli in saliva and plaque samples was detected by semi-quantitative RT-PCR using 16S rRNA primers.

Results: Periodontal clinical parameters were improved in both groups after an 8-week intervention. Current smokers in the test group showed a significantly greater improvement of plaque index and probing pocket depth from BL when compared with those in the placebo group. Salivary Lf level was also significantly decreased in the test group smokers.

Conclusion: Our results indicate that probiotics could be useful in the improvement/maintenance of oral health in subjects at a high risk of periodontal disease.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusImproved Periodontal HealthBeneficial
Moderate
Lactobacillus SalivariusReduced Salivary Lf Level in SmokersBeneficial
Moderate
Lactobacillus salivarius BLIS K12Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius BLIS K12Reduced Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Plaque IndexBeneficial
Moderate
Lactobacillus salivarius CRL 1328Reduced Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius HA-118Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius HA-118Reduced Probing DepthBeneficial
Large
Lactobacillus salivarius HA-118Reduced Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5208Decreased Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5208Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius SD-5851Decreased Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5851Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius SD-5851Improved Plaque IndexBeneficial
Moderate
Lactobacillus salivarius SD-5851Reduced Probing DepthBeneficial
Large
Lactobacillus salivarius UALb-07Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius UALb-07Improved Plaque IndexBeneficial
Moderate
Lactobacillus salivarius UALb-07Reduced Probing DepthBeneficial
Large
Lactobacillus salivarius UALb-07Reduced Salivary Lactoferrin LevelsBeneficial
Moderate
Lactobacillus salivarius UALs07Improved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius UALs07Reduced Plaque IndexBeneficial
Large
Lactobacillus salivarius UALs07Reduced Probing DepthBeneficial
Large
Lactobacillus salivarius UALs07Reduced Salivary Lf Level in SmokersBeneficial
Moderate
Lactobacillus salivarius UALs07 UASImproved Periodontal HealthBeneficial
Moderate
Lactobacillus salivarius UALs07 UASReduced Salivary Lf Level in SmokersBeneficial
Moderate
Lactobacillus salivarius VPro 15Reduced Plaque Index in SmokersBeneficial
Large
Lactobacillus salivarius VPro 15Reduced Probing DepthsBeneficial
Large
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