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In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12

  • 2020-11-12
  • Probiotics and Antimicrobial Proteins 13(3)
    • Tzu Yu Chen
    • J. Hale
    • J. Tagg
    • Rohit Jain
    • Abigail L. Voss
    • N. Mills
    • E. Best
    • D. S. Stevenson
    • Philip A. Bird
    • T. Walls


Otitis media is a common childhood infection, frequently requiring antibiotics. With high rates of antibiotic prescribing and increasing antibiotic resistance, new strategies in otitis media prevention and treatment are needed. The aim of this study was to assess the in vitro inhibitory activity Streptococcus salivarius BLIS K12 against otitis media pathogens. Efficacy of the bacteriocin activity of S. salivarius BLIS K12 against the otitis media isolates was assessed using the deferred antagonism test. Overall, 48% of pathogenic isolates exhibited some growth inhibition by S. salivarius BLIS K12. S. salivarius BLIS K12 can inhibit the in vitro growth of the most common pathogens.

Keywords: In vitro inhibition; Otitis media; Otitis media pathogens; Probiotics; Recurrent otitis media; S. salivarius BLIS K12.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus salivarius BLIS K12Reduced Acute Otitis MediaBeneficial
Streptococcus salivarius BLIS K12Inhibition of Otitis Media Pathogens GrowthBeneficial
Streptococcus salivarius K12Reduced Pathogenic GrowthBeneficial
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