Skip to main content

Abstract

Probiotic bacteria increase the host health status and protect mucosal tissue against pathogen-caused damage in mammalian models. Using an in vitro (intestinal sac) method this study aimed to address (a) the in vitro ability of Lactobacillus delbrueckii subsp. lactis to remain in the gastrointestinal tract of Atlantic salmon (Salmo salar L.) and (b) its ability to prevent cellular damage caused by successive incubation with Aeromonas salmonicida subsp. salmonicida the causative agent of furunculosis. Short in vitro incubation of salmon foregut with (TRITC)-labelled L. delbrueckii subsp. lactis showed that the probiont was able to colonize the enterocyte surface as studied by confocal microscopy. Furthermore, foregut incubated with the probiotic bacteria only, resulted in a healthy intestinal barrier whereas exposure to A. salmonicida disrupted its integrity. However, pre-treatment of salmon intestine with L. delbrueckii subsp. lactis prevented Aeromonas damaging effects. These results are promising in the context of the use of non-autochthonous probiotic bacteria as prophylactic agents against fish bacterial infections in the gastrointestinal tract.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus delbrueckiiEnterocyte Surface ColonizationBeneficial
Moderate
Lactobacillus delbrueckiiImproved Intestinal Barrier IntegrityBeneficial
Moderate
Lactobacillus delbrueckiiProtection Against Cellular Damage Induced by PathogensBeneficial
Large
Lactobacillus delbrueckii VPro 315Enterocyte Surface ColonizationBeneficial
Moderate
Lactobacillus delbrueckii VPro 315Improved Epithelial ProtectionBeneficial
Large
Lactobacillus delbrueckii VPro 315Maintained Intestinal Barrier FunctionBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.