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Abstract

Background/purpose: Our previous study revealed that probiotic Lactobacillus paracasei SD1 could reduce mutans streptococci as evaluated by cultivation-method as well as stimulate innate immunity. This study aimed to further investigate the effect of the probiotic on various oral bacteria by real-time PCR and salivary IgA levels.

Materials and methods: Forty children were included by randomization from either probiotic or control group in the previous study. The probiotic or control received milk-powder with or without L. paracasei SD1, respectively once daily for 6 months. Saliva were collected at baseline 3-, 6-, and 12-months and were evaluated for total bacteria, total lactobacilli (TL), L. paracasei/L. casei (LP/LC), total streptococci (TS) and Streptococcus mutans using the real-time PCR. The salivary IgA (sIgA) was examined using the ELISA method.

Results: All target bacterial levels were not significantly different at baseline in both groups. After milk-powder consumption, TL and LP/LC levels were significantly increased in the probiotic group, whereas TS and S. mutans levels were significantly decreased compared to baseline. TS and S. mutans levels were significantly lower, while the sIgA was greater in the probiotic compared to the control group. In the probiotic group, a positive correlation was found between LP/LC and sIgA, while negative correlations were observed between TS or S. mutans levels and sIgA.

Conclusion: L. paracasei SD1 could control S. mutans level and could stimulate sIgA. Results indicate that the L. paracasei SD1 strain may have a benefit for prevention of dental caries.

Keywords: Cariogenic bacteria; Dental caries; Lactobacillus paracasei SD1; Probiotic; Salivary IgA; Streptococcus mutans.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus paracasei 431Increased Salivary IgA LevelsBeneficial
Moderate
Lactobacillus paracasei 431Reduced Streptococcus Mutans LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Increased Levels of Lactobacillus Paracasei/CaseiBeneficial
Moderate
Lactobacillus paracasei DSM 13434Increased Salivary sIgA LevelsBeneficial
Moderate
Lactobacillus paracasei DSM 13434Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
Lactobacillus paracasei LPC09Increased Salivary IgA LevelsBeneficial
Moderate
Lactobacillus paracasei LPC09Reduced Streptococcus Mutans LevelsBeneficial
Moderate
Lactobacillus paracasei VPro 224Increased Salivary sIgA LevelsBeneficial
Moderate
Lactobacillus paracasei VPro 224Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
Lactobacillus salivarius SD-5208Increased Levels of Lactobacillus Paracasei/CaseiBeneficial
Moderate
Lactobacillus salivarius SD-5208Increased Salivary sIgA LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5208Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate
Lactobacillus salivarius SD-5851Increased Salivary sIgA LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5851Reduced Cariogenic Bacteria LevelsBeneficial
Moderate
Lactobacillus salivarius SD-5851Reduced Salivary Levels of Mutans StreptococciBeneficial
Moderate

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