Inflammaging-Driven Osteoporosis: Is a Galectin-Targeted Approach Needed?
- 2025-07-04
- International journal of molecular sciences 26(13)
- Marina Russo
- Caterina Claudia Lepre
- Annalisa Itro
- Gabriele Martin
- Gianluca Conza
- Maria Consiglia Trotta
- Monica Puticiu
- Anca Hermenean
- Francesca Gimigliano
- Michele D'Amico
- Giuseppe Toro
- PubMed: 40650248
- DOI: 10.3390/ijms26136473
Study Design
- Type
- Review
- Rigorous Journal
Osteoporosis (OP) is a chronic disease characterized by reduced bone mass and altered microarchitecture, leading to bone fragility and fractures. Due to its high morbidity, disability, and healthcare costs, identifying new biomarkers and therapeutic strategies is crucial for improving OP diagnosis and prevention. In this context, this narrative review aims to depict the role of carbohydrate-binding proteins Galectins (Gals) in the combined processes of inflammation and aging contributing to bone fragility by exploring their potential as novel therapeutic targets for OP.