Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

2022-10-31
Frontiers in nutrition 9
- Yujia Zhang
- Yiwang Ding
- Yawen Fan
- Yenan Xu
- Yuting Lu
- Lingzi Zhai
- Ling Wang

PubMed: 36386951
DOI: 10.3389/fnut.2022.1046800

Study Design

Type: Systematic Review
Sample size: n = 445
Population: patients with type 2 diabetes mellitus (T2DM)
Methods: We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. Pooled effects were measured by weighted mean differences (WMDs) with 95% confidence intervals (CI) using random effects models.
Duration: 28 to 90 days

Background

Biotin is a water-soluble vitamin acting as a covalently bound coenzyme in regulating energy production. Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabetes mellitus (T2DM).

Methods

We searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. Pooled effects were measured by weighted mean differences (WMDs) with 95% confidence intervals (CI) using random effects models. Inter-study heterogeneity was assessed and quantified.

Results

A total of five random controlled trials (RCT), involving 445 participants were included. It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: -1.21 mmol/L, 95% CI: -2.73 to 0.31), total cholesterol (TC) (MD: -0.22 mmol/L, 95% CI: -0.25 to -0.19) and triglycerides (TG) (MD: -0.59 mmol/L, 95% CI: -1.21 to 0.03). No significant beneficial effects were observed on insulin (MD: 1.88 pmol/L 95% CI: -13.44 to 17.21). Evidence for the impact of biotin supplementation on the levels of glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) was limited to draw conclusion.

Conclusions

Biotin supplementation may decrease FBG, TC and TG levels. However, its influence on insulin is not significant and further studies on the effects of biotin on HbA1c, LDL-C, HDL-C and VLDL-C are expected.

Research Insights

Vitamin B7→Reduced Fasting Blood Glucose Levels
It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: -1.21 mmol/L, 95% CI: -2.73 to 0.31)
Effect
Neutral
Effect size
Moderate
Vitamin B7→Reduced Total Cholesterol
total cholesterol (TC) (MD: -0.22 mmol/L, 95% CI: -0.25 to -0.19)
Effect
Beneficial
Effect size
Small
Vitamin B7→Reduced Triglyceride Levels
triglycerides (TG) (MD: -0.59 mmol/L, 95% CI: -1.21 to 0.03)
Effect
Neutral
Effect size
Moderate
Vitamin B7→Unchanged Insulin Level
No significant beneficial effects were observed on insulin (MD: 1.88 pmol/L 95% CI: -13.44 to 17.21)
Effect
Neutral
Effect size
Small