Inhibitory effects of Lactobacillus brevis KU15153 against Streptococcus mutans KCTC 5316 causing dental caries.
- 2021-08
- Microbial Pathogenesis 157
- H. Jang
- Jong Ha Kim
- N. Lee
- H. Paik
- PubMed: 34022360
- DOI: 10.1016/j.micpath.2021.104938
Abstract
This study determined the inhibitory effect of Lactobacillus brevis KU15153 against cariogenic Streptococcus mutans KCTC 5316. Antimicrobial activity, auto-aggregation, cell surface hydrophobicity, exopolysaccharides (EPS) production, biofilm formation, and morphological changes were assessed in the presence of L. brevis KU15153. L. brevis KU15153 exhibited the highest antimicrobial activity against S. mutans KCTC 5316 (28.67 ± 4.16 mm). Auto-aggregation (38.32%), cell surface hydrophobicity (27.08%), and EPS production rate (58.52%) of S. mutans KCTC 5316 slightly decreased upon treatment with L. brevis KU15153. Additionally, crystal violet stanning and scanning electron microscopy confirmed the L. brevis KU15153-mediated inhibition of biofilm formation by S. mutans KCTC 5316 in comparison to that observed in the negative control (untreated S. mutans KCTC 5316). These results indicate that the L. brevis KU15153 could be used as a potential probiotic for maintaining oral health.
Keywords: Antibiofilm effect; Anticavity effect; Antimicrobial effect; Oral health; Probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus brevis | Reduced Biofilm Formation | Beneficial | Moderate |
| Lactobacillus brevis | Reduced Cariogenic Bacteria | Beneficial | Large |
| Lactobacillus brevis SD-5214 | Reduced Biofilm Formation | Beneficial | Moderate |
| Lactobacillus brevis SD-5214 | Reduced Streptococcus mutans Colonization | Beneficial | Large |