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Abstract

Lactiplantibacillus plantarum MTCC 2621 is a well-characterized probiotic strain and is reported to possess many health benefits. However, the wound healing potential of this probiotic is yet to be explored. Here, we have assessed the antibacterial, antioxidant, and wound healing activities of cell-free supernatant of Lactiplantibacillus plantarum MTCC 2621 (Lp2621). Lp2621 exhibited excellent antibacterial activity against the indicator bacteria in the agar well diffusion assay. Lp2621 did not show any hemolytic activity. The safety of Lp2621 gel was established using the skin irritation assay in BALB/c mice, and no dermal reactions were observed. The supernatant showed 60-100% protection of A549 cells against H2O2-induced stress. In the scratch assay, Lp2621 accelerated wound healing after 24 h of treatment. The percent wound healing was significantly higher in cells treated with Lp2621 at 18-24 h posttreatment. In an excision wound healing in mice, topical application of Lp2621 gel showed faster healing than the vehicle- and betadine-treated groups. Similar wound healing activity was observed in wounds infected with Staphylococcus aureus. Histological examination revealed better wound healing in Lp2621-treated mice. Topical treatment of the wounds with Lp2621 gel resulted in the upregulation of pro-inflammatory cytokine IL-6 in the early phase of wound healing and enhanced IL-10 expression in the later phase. These findings unveil a protective role of Lp2621 against bacterial infection, oxidative stress, and wound healing.

Keywords: A549 cells; BALB/c mice; Lactiplantibacillus plantarum; cell-free supernatant; inflammation; oxidative stress; wound healing.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarumEnhanced Anti-inflammatory Cytokine Expression During HealingBeneficial
Moderate
Lactiplantibacillus plantarumEnhanced Safety in Topical ApplicationNeutral
Small
Lactiplantibacillus plantarumImproved Histological Wound HealingBeneficial
Large
Lactiplantibacillus plantarumImproved Wound HealingBeneficial
Large
Lactiplantibacillus plantarumIncreased Antibacterial ActivityBeneficial
Large
Lactiplantibacillus plantarumIncreased Pro-inflammatory Cytokine ExpressionBeneficial
Moderate
Lactiplantibacillus plantarumProtection Against Oxidative StressBeneficial
Large
Lactiplantibacillus plantarum KABP™-022Accelerated Wound HealingBeneficial
Large
Lactiplantibacillus plantarum KABP™-022Enhanced Interleukin-10 ExpressionBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Improved Wound HealingBeneficial
Large
Lactiplantibacillus plantarum KABP™-022Increased Antibacterial ActivityBeneficial
Large
Lactiplantibacillus plantarum KABP™-022Increased Pro-inflammatory Cytokine IL-6Beneficial
Moderate
Lactiplantibacillus plantarum KABP™-022Reduced Hepatic Oxidative StressBeneficial
Large
Lactiplantibacillus plantarum KABP™-023Absence of Hemolytic ActivityBeneficial
Large
Lactiplantibacillus plantarum KABP™-023Enhanced Interleukin-10 ExpressionBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Improved Wound Healing in Infected WoundsBeneficial
Large
Lactiplantibacillus plantarum KABP™-023Increased Antibacterial ActivityBeneficial
Large
Lactiplantibacillus plantarum KABP™-023Increased IL-6 Levels in Early PhaseBeneficial
Moderate
Lactiplantibacillus plantarum KABP™-023Protection Against Oxidative StressBeneficial
Large
Lactiplantibacillus plantarum LP-1Enhanced Interleukin-10 ExpressionBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Improved Wound HealingBeneficial
Large
Lactiplantibacillus plantarum LP-1Improved Wound Healing in Infected WoundsBeneficial
Large
Lactiplantibacillus plantarum LP-1Increased Antibacterial ActivityBeneficial
Large
Lactiplantibacillus plantarum LP-1Increased Pro-inflammatory Cytokine IL-6Beneficial
Moderate
Lactiplantibacillus plantarum LP-1Protection Against Oxidative StressBeneficial
Large
Lactiplantibacillus plantarum Lp-115Enhanced Anti-inflammatory Cytokine Expression During HealingBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Enhanced Wound Healing in InfectionsBeneficial
Large
Lactiplantibacillus plantarum Lp-115Improved Histological HealingBeneficial
Large
Lactiplantibacillus plantarum Lp-115Improved Wound Healing In VitroBeneficial
Large
Lactiplantibacillus plantarum Lp-115Improved Wound Healing In VivoBeneficial
Large
Lactiplantibacillus plantarum Lp-115Increased Antibacterial ActivityBeneficial
Large
Lactiplantibacillus plantarum Lp-115Increased Pro-inflammatory Cytokines in Early Healing PhaseBeneficial
Moderate
Lactiplantibacillus plantarum Lp-115Non-hemolytic SafetyBeneficial
Large
Lactiplantibacillus plantarum Lp-115Protection Against Oxidative StressBeneficial
Large
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