Insight into the pharmacological effects of andrographolide in musculoskeletal disorders.
- 2022-02
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 146
- Ming-Yang Liu
- Hai-Jun Li
- Chen Yang
- Wei-Dong Zang
- Zhen-Dong Liu
- Liang Zhang
- Pan-Hui Li
- Yong-Jie Zhu
- Yao-Ye Zhao
- Run-Ze Liu
- Yan-Zheng Gao
- PubMed: 34954644
- DOI: 10.1016/j.biopha.2021.112583
Study Design
- Type
- Review
- Funding
- Unclear
Andrographis paniculata (A. paniculata) is a traditional herbal medicine that has been widely used in Asian countries for hundreds of years. Andrographolide (AG) is a diterpene lactone extracted from A. paniculata. Owing to the in-depth study of pharmacological mechanisms, the therapeutic potential of AG, including its anti-inflammatory, anti-tumor, and immunoregulatory attributes, has attracted the attention of many researchers. Studies testing the therapeutic effects of AG have demonstrated desirable results in the treatment of a variety of clinical diseases. With high safety and various biological functions, AG might be a promising candidate for the treatment of musculoskeletal disorders. Here, we review all available literatures to summarize the pharmacological effects of AG and facilitate further researches on musculoskeletal diseases.