Intake of fermented soybean (natto) increased locomotor activity in mice.
- 2007
- Biological and Pharmaceutical Bulletin 30(4)
- T. Mamiya
- A. Nishimura
- PubMed: 17409536
- DOI: 10.1248/BPB.30.845
Abstract
We fed mice food granules containing fermented soybean (natto in Japanese) powder (hereafter "natto granules") for 14 d to investigate whether natto granules had any effects on mouse behavior. We noted an enhancement of locomotor activity in natto-granule-fed mice compared to control and soybean-pellet-fed mice. This enhanced locomotor activity was blocked by a low dose of haloperidol (1 microg/kg i.p.), a dopamine receptor antagonist, but not by methysergide, a serotonin 5-HT(1/2) receptor antagonist. The results suggest that the enhanced locomotor activity induced by continuous intake of natto granules in mice is sensitive to haloperidol.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Natto | Increased Locomotor Activity During Active Phase | Beneficial | Moderate |