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Both heat-killed Lactobacillus plantarum (HK-LP) and β-glucan (BG) play important roles in growth performance, feed utilization and health status of fish. Therefore, a feeding trial was conducted to determine the interactive effects of dietary HK-LP and BG on growth performance, digestibility, oxidative status and immune response of red sea bream for 56 days. A significant interaction was found between HK-LP and BG on final body weight, total plasma protein, glucose, serum bactericidal activity (BA), total serum protein, serum alternative complement pathway (ACP) activity, protein and dry matter digestibility coefficients (P < 0.05). In addition, body weight gain, specific growth rate, feed intake, protein efficiency ratio as well as serum lysozyme activity, ACP activity and mucus secretion were significantly affected by either HK-LP or BG (P < 0.05). Further, feeding 0.025% HK-LP combined with 0.1% BG significantly increased serum peroxidase activity compared with the other groups (P < 0.05). However, protein body content, somatic parameters, total bilirubin, blood urea nitrogen, glutamyl oxaloacetic transaminase (GOT), glutamic-pyruvate transaminase (GPT), triglycerides and mucus BA were not significantly altered by supplementations (P > 0.05). Interestingly, fish fed with both HK-LP at (0.025 and 0.1%) in combination with BG at (0 and 0.1%) showed higher oxidative stress resistance. Under the experimental conditions, dietary HK-LP and BG had a significant interaction on enhancing the growth, digestibility and immune responses of red sea bream.

Keywords: Growth; Heat-killed Lactobacillus plantarum; Immunity; Red sea bream; β-glucan.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum LP-01Improved DigestibilityBeneficial
Lactobacillus plantarum LP-01Improved Growth PerformanceBeneficial
Lactobacillus plantarum LP-01Improved Immune ResponseBeneficial
Lactobacillus plantarum LP-01Improved Oxidative Stress ResistanceBeneficial
Lactobacillus plantarum Lp-115Improved DigestibilityBeneficial
Lactobacillus plantarum Lp-115Improved Immune ResponseBeneficial
Lactobacillus plantarum Lp-115Improved Oxidative Stress ResistanceBeneficial
Lactobacillus plantarum Lp-115Increased Serum Peroxidase ActivityBeneficial

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