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Abstract

There is an increasing interest in the intestinal and immunological effects of probiotics. The aim of the present study is to evaluate the tolerance and beneficial effects in healthy adults of the strain, Lactobacillus salivarius CECT5713 isolated from breast milk. A phase II, randomized, double-blinded, placebo-controlled human clinical trial was carried out in 40 healthy adults. The Probiotic group received a daily dose of 2 x 10(8) CFU of L. salivarius CECT5713 in capsules during 4 weeks while volunteers of the control received only a placebo. Gastrointestinal and immunological parameters were analyzed. Results showed that L. salivarius CECT5713 was well tolerated and no adverse effects were detected. Consumption of the probiotic strain increased fecal lactobacilli counts (7.9+/-0.1 vs. 7.05+/-0.2 CFU/g feces, P=0.001). Also, an improvement in the frequency of defecation (P=0.04) was observed. Probiotic treatment induced significantly the percentage of NK cells and monocytes, as well as the plasmatic levels of immunoglobulins M, A and G, and the regulatory cytokine IL-10 (72.3+/-11.7 in probiotic group vs. 27.3+/-6.4 pg/mL in control group, P<0.01). Thus, it can be concluded that daily administration of L. salivarius CECT5713 to healthy adults is safe and improve gut microbiota and different parameters related to immune response.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus SalivariusImproved Bowel Movement FrequencyBeneficial
Small
Lactobacillus SalivariusIncreased Fecal LactobacilliBeneficial
Moderate
Lactobacillus SalivariusIncreased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius BLIS K12Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius BLIS K12Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius CRL 1328Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius CRL 1328Increased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius CRL 1328Increased Lactobacillus CountsBeneficial
Large
Lactobacillus salivarius HA-118Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius HA-118Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius HA-118Increased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius SD-5208Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius SD-5208Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius SD-5208Increased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius SD-5851Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius SD-5851Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius SD-5851Increased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius UALb-07Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius UALb-07Increased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius UALb-07Increased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius UALs07Improved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius UALs07Improved Gut MicrobiotaBeneficial
Moderate
Lactobacillus salivarius UALs07Improved Immune ResponseBeneficial
Large
Lactobacillus salivarius UALs07 UASImproved Bowel Movement FrequencyBeneficial
Small
Lactobacillus salivarius UALs07 UASIncreased Fecal LactobacilliBeneficial
Moderate
Lactobacillus salivarius UALs07 UASIncreased Interleukin-10 LevelsBeneficial
Large
Lactobacillus salivarius UALs07 UASNo Reported Adverse EffectsNeutral
Large
Lactobacillus salivarius VPro 15Increased Plasma Immunoglobulin LevelsBeneficial
Moderate

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