Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial

2016-07
Journal of Pediatric Gastroenterology and Nutrition 63(1)
- T. Okazaki
- T. Asahara
- A. Yamataka
- Yuki Ogasawara
- Geoffrey J. Lane
- K. Nomoto
- S. Nagata
- Y. Yamashiro

PubMed: 26859092
DOI: 10.1097/MPG.0000000000001140

Abstract

The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.

Research Insights

Supplement	Health Outcome	Effect Type	Effect Size
Bifidobacterium breve Bb-03	Elevated Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve Bb-03	Improved Intestinal Health	Beneficial	Large
Bifidobacterium breve Bb-03	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve Bb-03	Reduced Blood Bacterial Incidence	Beneficial	Large
Bifidobacterium breve Bb-03	Reduced Clostridium Difficile Levels	Beneficial	Moderate
Bifidobacterium breve Bb-03	Reduced Enterobacteriaceae Levels in Feces	Beneficial	Moderate
Bifidobacterium breve Bb-03	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve Bb-03	Reduced Pseudomonas in Feces	Beneficial	Moderate
Bifidobacterium breve Bb-18	Elevated Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve Bb-18	Increased Fecal Acetic Acid Concentration	Beneficial	Moderate
Bifidobacterium breve Bb-18	Reduced Blood Bacterial Incidence	Beneficial	Large
Bifidobacterium breve Bb-18	Reduced Faecal pH	Neutral	Small
Bifidobacterium breve Bb-18	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve Bbr8	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve Bbr8	Increased Intestinal Bifidobacteria Population	Beneficial	Large
Bifidobacterium breve Bbr8	Reduced Bacterial Load in Blood	Beneficial	Large
Bifidobacterium breve Bbr8	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve BR-03	Improved Intestinal Microenvironment	Beneficial	Large
Bifidobacterium breve BR-03	Increased Fecal Acetic Acid Concentration	Beneficial	Moderate
Bifidobacterium breve BR-03	Increased Fecal Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve BR-03	Reduced Bacterial Levels in Blood	Beneficial	Moderate
Bifidobacterium breve BR-03	Reduced Enterobacteriaceae Levels in Feces	Beneficial	Moderate
Bifidobacterium breve BR-03	Reduced Fecal Clostridium difficile	Beneficial	Moderate
Bifidobacterium breve BR-03	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve BR-03	Reduced Pseudomonas in Feces	Beneficial	Moderate
Bifidobacterium breve HA-129	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve HA-129	Increased Intestinal Bifidobacteria Levels	Beneficial	Large
Bifidobacterium breve HA-129	Reduced Clostridium Difficile in Intestines	Beneficial	Large
Bifidobacterium breve HA-129	Reduced Enterobacteriaceae in Intestines	Beneficial	Large
Bifidobacterium breve HA-129	Reduced Faecal pH	Neutral	Small
Bifidobacterium breve HA-129	Reduced Incidence of Bacteremia	Beneficial	Large
Bifidobacterium breve HA-129	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve HA-129	Reduced Pseudomonas in Feces	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Elevated Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Reduced Bacterial Detection in Blood	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Reduced Clostridium difficile Count	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Reduced Enterobacteriaceae Counts	Beneficial	Moderate
Bifidobacterium breve MAK40B22B	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve MAK40B22B	Reduced Pseudomonas in Feces	Beneficial	Moderate
Bifidobacterium breve R0070	Improved Intestinal Health	Beneficial	Large
Bifidobacterium breve R0070	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve R0070	Increased Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve R0070	Reduced Incidence of Bacteremia	Beneficial	Large
Bifidobacterium breve R0070	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve SD5206	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve SD5206	Increased Fecal Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve SD5206	Reduced Clostridium difficile Count	Beneficial	Moderate
Bifidobacterium breve SD5206	Reduced Enterobacteriaceae Counts	Beneficial	Moderate
Bifidobacterium breve SD5206	Reduced Pseudomonas in Feces	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Elevated Bifidobacterium Levels	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Increased Acetic Acid Levels in Feces	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Reduced Bacteremia	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Reduced Clostridium difficile Count	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Reduced Enterobacteriaceae Counts	Beneficial	Moderate
Bifidobacterium breve UABbr-11	Reduced Postoperative Infectious Complications	Beneficial	Large
Bifidobacterium breve UABbr-11	Reduced Pseudomonas in Feces	Beneficial	Moderate