Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial

2016-07
Journal of Pediatric Gastroenterology and Nutrition 63(1)
- T. Okazaki
- T. Asahara
- A. Yamataka
- Yuki Ogasawara
- Geoffrey J. Lane
- K. Nomoto
- S. Nagata
- Y. Yamashiro

PubMed: 26859092
DOI: 10.1097/MPG.0000000000001140

Study Design

Type: Randomized Controlled Trial (RCT)
Population: Pediatric surgical patients
Methods: Controlled experimental study

Abstract

The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.

Research Insights

Bifidobacterium breve MAK40B22B→Elevated Bifidobacterium Levels
Fecal analysis showed increased Bifidobacterium.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Increased Acetic Acid Levels in Feces
Concentrations of fecal acetic acid were significantly increased
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Reduced Bacterial Detection in Blood
The incidence of detecting bacteria in blood was significantly reduced.
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Reduced Clostridium difficile Count
Fecal analysis showed... decreased Clostridium difficile
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Reduced Enterobacteriaceae Counts
Fecal analysis showed... decreased Enterobacteriaceae
Effect
Beneficial
Effect size
Moderate
Bifidobacterium breve MAK40B22B→Reduced Postoperative Infectious Complications
postoperative infectious complications were significantly decreased.
Effect
Beneficial
Effect size
Large
Bifidobacterium breve MAK40B22B→Reduced Pseudomonas in Feces
Fecal analysis showed... decreased Pseudomonas
Effect
Beneficial
Effect size
Moderate