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Intestinal Microbiota in Pediatric Surgical Cases Administered Bifidobacterium Breve: A Randomized Controlled Trial

  • 2016-07
  • Journal of Pediatric Gastroenterology and Nutrition 63(1)
    • T. Okazaki
    • T. Asahara
    • A. Yamataka
    • Yuki Ogasawara
    • Geoffrey J. Lane
    • K. Nomoto
    • S. Nagata
    • Y. Yamashiro

Abstract

The efficacy of perioperative probiotic administration has been reported in adults. We examined the effects of orally administered Bifidobacterium breve strain Yakult (BBG-01) on outcomes in pediatric surgical cases by assessing intestinal and blood microbiota. BBG-01 was well tolerated without adverse effects, and postoperative infectious complications were significantly decreased. Fecal analysis showed increased Bifidobacterium and decreased Enterobacteriaceae, Clostridium difficile, and Pseudomonas. Concentrations of fecal acetic acid were significantly increased, maintaining fecal pH at <7.0. The incidence of detecting bacteria in blood was significantly reduced. BBG-01 improved the intestinal environment, and may be implicated in suppressing bacterial translocation.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium breve Bb-03Elevated Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve Bb-03Improved Intestinal HealthBeneficial
Large
Bifidobacterium breve Bb-03Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Blood Bacterial IncidenceBeneficial
Large
Bifidobacterium breve Bb-03Reduced Clostridium Difficile LevelsBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Enterobacteriaceae Levels in FecesBeneficial
Moderate
Bifidobacterium breve Bb-03Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve Bb-03Reduced Pseudomonas in FecesBeneficial
Moderate
Bifidobacterium breve Bb-18Elevated Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve Bb-18Increased Fecal Acetic Acid ConcentrationBeneficial
Moderate
Bifidobacterium breve Bb-18Reduced Blood Bacterial IncidenceBeneficial
Large
Bifidobacterium breve Bb-18Reduced Faecal pHNeutral
Small
Bifidobacterium breve Bb-18Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve Bbr8Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve Bbr8Increased Intestinal Bifidobacteria PopulationBeneficial
Large
Bifidobacterium breve Bbr8Reduced Bacterial Load in BloodBeneficial
Large
Bifidobacterium breve Bbr8Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve BR-03Improved Intestinal MicroenvironmentBeneficial
Large
Bifidobacterium breve BR-03Increased Fecal Acetic Acid ConcentrationBeneficial
Moderate
Bifidobacterium breve BR-03Increased Fecal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Bacterial Levels in BloodBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Enterobacteriaceae Levels in FecesBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Fecal Clostridium difficileBeneficial
Moderate
Bifidobacterium breve BR-03Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve BR-03Reduced Pseudomonas in FecesBeneficial
Moderate
Bifidobacterium breve HA-129Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve HA-129Increased Intestinal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium breve HA-129Reduced Clostridium Difficile in IntestinesBeneficial
Large
Bifidobacterium breve HA-129Reduced Enterobacteriaceae in IntestinesBeneficial
Large
Bifidobacterium breve HA-129Reduced Faecal pHNeutral
Small
Bifidobacterium breve HA-129Reduced Incidence of BacteremiaBeneficial
Large
Bifidobacterium breve HA-129Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve HA-129Reduced Pseudomonas in FecesBeneficial
Moderate
Bifidobacterium breve MAK40B22BElevated Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve MAK40B22BIncreased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Bacterial Detection in BloodBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Clostridium difficile CountBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium breve MAK40B22BReduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve MAK40B22BReduced Pseudomonas in FecesBeneficial
Moderate
Bifidobacterium breve R0070Improved Intestinal HealthBeneficial
Large
Bifidobacterium breve R0070Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve R0070Increased Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve R0070Reduced Incidence of BacteremiaBeneficial
Large
Bifidobacterium breve R0070Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve SD5206Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve SD5206Increased Fecal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Clostridium difficile CountBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium breve SD5206Reduced Pseudomonas in FecesBeneficial
Moderate
Bifidobacterium breve UABbr-11Elevated Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium breve UABbr-11Increased Acetic Acid Levels in FecesBeneficial
Moderate
Bifidobacterium breve UABbr-11Reduced BacteremiaBeneficial
Moderate
Bifidobacterium breve UABbr-11Reduced Clostridium difficile CountBeneficial
Moderate
Bifidobacterium breve UABbr-11Reduced Enterobacteriaceae CountsBeneficial
Moderate
Bifidobacterium breve UABbr-11Reduced Postoperative Infectious ComplicationsBeneficial
Large
Bifidobacterium breve UABbr-11Reduced Pseudomonas in FecesBeneficial
Moderate

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