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Intravaginal Aloe barbadensis and cervical HPV clearance: A retrospective observational study.

  • 2026-07-01
  • Pakistan journal of pharmaceutical sciences 39(7)
    • Belma Gozde Ozdemir
    • Fazil Avci
    • Leyla Huseynli
    • Rana Dolas
    • Ahmet Bilgi
    • Cetin Celik

Study Design

Type
Observational
Population
251 HPV-positive women aged ≥30 years
Methods
retrospective observational study; 164 received intravaginal Aloe barbadensis-containing vaginal capsules for 10 days, while 87 received no immunomodulatory treatment
Duration
one year of follow-up
Funding
Unclear

Background

Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.

Objectives

This study aimed to evaluate the association between intravaginal Aloe barbadensis use and HPV clearance in HPV-positive women.

Methods

This retrospective observational study included 251 HPV-positive women aged ≥30 years. Of these, 164 received intravaginal Aloe barbadensis-containing vaginal capsules for 10 days, while 87 received no immunomodulatory treatment. HPV-PCR and cytological results were evaluated at baseline and after one year of follow-up.

Results

HPV clearance was observed in 45.7% of patients in the Aloe barbadensis group and 36.8% in the control group, with no statistically significant difference between groups (p = 0.219). Subgroup analyses based on smoking status and HPV genotype also revealed no significant differences in clearance rates.

Conclusion

Intravaginal Aloe barbadensis use was not associated with a statistically significant improvement in HPV clearance. The findings highlight the complexity of HPV persistence and suggest that single-agent immunomodulatory interventions may have limited clinical impact.

Research Insights

  • Aloe→Cleared HPV Infection

    HPV clearance was observed in 45.7% of patients in the Aloe barbadensis group and 36.8% in the control group, with no statistically significant difference between groups (p = 0.219).

    Effect
    Neutral
    Effect size
    Small
  • Aloe→Improved HPV Clearance

    HPV clearance was observed in 45.7% of patients in the Aloe barbadensis group and 36.8% in the control group, with no statistically significant difference between groups (p = 0.219).

    Effect
    Neutral
    Effect size
    Small
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