Involvement of Nrf2 in Ocular Diseases.
- 2017-01
- Oxidative medicine and cellular longevity 2017(1)
- Shehzad Batliwala
- Christy Xavier
- Yang Liu
- Hongli Wu
- Iok-Hou Pang
- PubMed: 28473877
- DOI: 10.1155/2017/1703810
Study Design
- Type
- Review
The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.