Ironing Out the Deficiency: Tracking Iron in Celiac Disease Before and After the Gluten-Free Diet.

2026-02-11
Nutrients 18(4)
- Patricia Dillawn
- Sadie Nagle
- Edwin Liu
- Marisa Gallant Stahl

PubMed: 41754107
DOI: 10.3390/nu18040590

Study Design

Type: Review
Population: individuals with CeD

Rigorous Journal

Celiac disease (CeD) is a gluten-induced immune-mediated enteropathy that preferentially involves the proximal duodenum. Consequently, iron deficiency is common in CeD, impacting at least 10% of newly diagnosed individuals. In this narrative review, we aim to investigate the mechanisms, prevalence, treatment, and monitoring of iron deficiency and the impacts of a gluten-free diet (GFD) on iron deficiency in individuals with CeD. We will also review the role of and approach to iron supplementation in this population. Specifically, we will explore whether mucosal healing on a GFD is sufficient for the management of iron deficiency amongst individuals with CeD.

Research Insights

Iron→Reduced Iron Deficiency
Celiac disease (CeD) is a gluten-induced immune-mediated enteropathy that preferentially involves the proximal duodenum. Consequently, iron deficiency is common in CeD, impacting at least 10% of newly diagnosed individuals.
Effect
Beneficial
Effect size
Moderate